2018 年第 8 期 第 13 卷

银花泌炎灵片联合抗菌药物治疗绝经后女性下尿路感染的临床效果

Clinical effect of Yinhua Miyanling tablets combined with antibiotics on postmenopausal female lower urinary tract infection

作者：王志刚陈铭邱云桥王峻刘鸿谢建兴

英文作者：

单位：510405广州中医药大学第一附属医院泌尿外科

英文单位：

关键词：女性下尿路感染；银花泌炎灵片；抗菌药物；绝经后

英文关键词：

• 摘要：

• 【摘要】目的    探究银花泌炎灵片联合抗菌药物治疗绝经后女性下尿路感染的临床效果。方法    选取2014年6月至2016年5月广州中医药大学第一附属医院收治的108例绝经后女性下尿路感染患者，采用随机数字表法分为对照组和观察组，每组54例。对照组患者口服左氧氟沙星治疗（0.2 g/次、2次/d），观察组患者在对照组基础上加服银花泌炎灵片（2.0 g/次、4次/d）治疗，均进行2周的治疗。比较2组患者的临床治疗有效率、尿液中白细胞数量、中医证候积分、不良反应情况、复发情况及患者对治疗效果满意度。结果    观察组的治疗总有效率明显高于对照组［100.0%（54/54）比87.0%（47/54）］（P＝0.019）。治疗后观察组尿液中白细胞数量明显少于对照组［（4.98±0.98）个/L比（6.01±0.23）个/L］（P＜0.001）。治疗后观察组尿频、尿急、尿痛、遇劳即发、腰膝酸软、尿道炽热、手足心热评分均明显低于对照组［（2.8±0.8）分比（4.9±1.8）分、（2.7±0.8）分比（4.1±1.2）分、（1.4±0.5）分比（3.2±1.1）分、（2.0±0.8）分比（2.9±1.0）分、（0.86±0.18）分比（1.85±0.50）分、（0.74±0.16）分比（1.32±0.39）分、（0.57±0.12）分比（1.08±0.15）分］，差异均有统计学意义（均P＜0.05）。2组不良反应发生率比较，差异无统计学意义（P＞0.05）。观察组复发率明显低于对照组［1.9%（1/54）比14.8%（8/54）］（P＝0.037）。观察组满意度明显高于对照组［98.1%（53/54）比85.2%（46/54）］（P＝0.037）。结论    银花泌炎灵片联合抗菌药物治疗绝经后女性下尿路感染能够提高临床有效率，降低复发率，治疗效果优于单纯抗菌药物治疗。

• Objective    To investigate the effect of Yinhua Miyanling tablets combined with antibiotics on postmenopausal women with lower urinary tract infection. Methods    A total of 108 cases of postmenopausal women with lower urinary tract infection were enrolled from June 2014 to May 2016 in the First Affiliated Hospital of Guangzhou University of Chinese Medicine. The patients were divided into control group and observation group, with 54 cases in each group. The control group took levofloxacin 0.2 g/time, 2 times/d; the observation group took levofloxacin plus Yinhua Miyanling 2.0 g /time, 4 times/d. Clinical therapeutic effect, white blood cell count in urine, Chinese medicine symptom score, adverse reactions, recurrence and patient satisfaction were analyzed. Results    Total effective rate in observation group was significantly higher than that in control group［100.0%（54/54） vs 87.0%（47/54）］（P＝0.019）. After treatment, urinary white blood cell count in observation group was significantly lower than that in control group［（4.98±0.98）/L vs （6.01±0.23）/L］（P＜0.001）. Scores of frequent urination, urgent urination, painful urination, stranguria due to overstrain, soreness and weakness of waist and knees, urethral fever, feverish palms and soles after treatment in observation group were significantly lower than those in control group［（2.8±0.8） vs （4.9±1.8）, （2.7±0.8） vs （4.1±1.2）, （1.4±0.5） vs （3.2±1.1）, （2.0±0.8） vs （2.9±1.0）, （0.86±0.18） vs （1.85±0.50）, （0.74±0.16） vs （1.32±0.39）, （0.57±0.12） vs （1.08±0.15）］(P＜0.05). Incidence of adverse reactions showed no significant difference between groups（P＞0.05）. Recurrence rate in observation group was significantly lower than that in control group［1.9%（1/54） vs 14.8%（8/54）］（P＝0.037）. Patient satisfaction degree in observation group was significantly higher than that in control group［98.1%（53/54） vs 85.2%（46/54）］（P＝0.037）. Conclusion    Yinhua Miyanling tablets combined with antibiotics treating postmenopausal female lower urinary tract infection can improve clinical efficacy and reduce recurrence.