2018 年第 9 期 第 13 卷

维生素E对2型糖尿病视网膜病变患者血清丙二醛水平的影响

Effect of vitamin E on serum malondialdehyde level in type 2 diabetes mellitus patients with retinopathy

作者：庞晓宁何晓一刘彦君

英文作者：

单位：721000陕西省宝鸡市，解放军第三医院内分泌代谢科

英文单位：

关键词：2型糖尿病；糖尿病视网膜病变；维生素E；氧化应激；丙二醛

英文关键词：

• 摘要：

• 【摘要】目的    探讨维生素E对2型糖尿病视网膜病变患者血清丙二醛水平的影响。方法    选取2016年6月至2017年6月解放军第三医院收治的266例2型糖尿病视网膜病变患者为研究对象。给予所有患者维生素E 100 mg/d，早餐后顿服，连续服用 3个月。通过眼科检查评估患者眼底情况，根据国际临床糖尿病性视网膜病变（DR）严重程度分级标准将患者分为非增殖型轻度DR组(Ⅰ组，69例)、中度DR组(Ⅱ组，61例)、重度DR组(Ⅲ组，47例)和增殖型DR组(Ⅳ组，89例)。比较治疗前后总体、不同DR程度分组、不同性别间血清丙二醛水平。结果    治疗前Ⅲ组、Ⅳ组血清丙二醛水平高于Ⅰ组患者［（4.42±0.15）、（4.84±0.17）μmol/L比（3.62±0.11）μmol/L］，差异有统计学意义（P<0.05或P<0.01）；治疗后Ⅰ、Ⅱ、Ⅲ、Ⅳ组血清丙二醛水平［（3.44±0.13）、（3.71±0.16）、（4.18±0.17）、（4.72±0.14）μmol/L］均低于治疗前，Ⅳ组仍高于Ⅰ组，差异均有统计学意义（均P<0.05）。男性及女性患者治疗前后各自组内丙二醛水平差异均无统计学意义（均P>0.05）。无论男性和女性，治疗后Ⅰ、Ⅱ、Ⅲ、Ⅳ组丙二醛水平均低于治疗前，差异均有统计学意义（均P<0.05）。结论    维生素E对血清丙二醛水平有影响，且与2型糖尿病患者的DR严重程度相关。

• 【Abstract】Objective    To investigate the effect of vitamin E on serum malondialdehyde level in type 2 diabetes mellitus patients with diabetic retinopathy(DR). Methods    From June 2016 to June 2017, 266 type 2 diabetic patients with DR were enrolled in the Third Hospital of the Chinese People′s Liberation Army. All patients took vitamin E 100 mg/d after breakfast for 3 months. Fundus condition was examined and the patients were divided into 4 groups according to the international grading standards: non-proliferative mild DR(group Ⅰ, n＝69), moderate DR(group Ⅱ, n＝61), severe DR(group Ⅲ, n＝47) and proliferative DR(group Ⅳ, n＝89). Serum malondialdehyde level was analyzed before and after treatment. Results    Before treatment, malondialdehyde in group Ⅲ and group Ⅳ was significantly higher than that in group Ⅰ［（4.42±0.15）,（4.84±0.17）μmol/L vs （3.62±0.11）μmol/L］（P<0.05 or P<0.01）. After treatment, malondialdehyde in group Ⅰ, Ⅱ, Ⅲ and Ⅳ［（3.44±0.13）,（3.71±0.16）,（4.18±0.17）,（4.72±0.14）μmol/L］ was significantly lower than that before treatment; malondialdehyde in group Ⅳ was significantly higher than that in group Ⅰ(P<0.05). There was no significant difference of malondialdehyde level between male and female patients before and after treatment(P>0.05). Whether in males or females, malondialdehyde in group Ⅰ, Ⅱ, Ⅲ and Ⅳ after treatment was significantly lower than that before treatment(P<0.05). Conclusion    Vitamin E has an effect on serum malondialdehyde level, which is related to the severity of DR in patients with type 2 diabetes.