2019 年第 4 期 第 14 卷

西帕依固龈液对慢性牙周炎患者牙周指标和龈沟液中细胞因子的影响

Effect of Xipayi mouth rinse on periodontal indexes and cytokines in gingival crevicular fluid in patients with chronic periodontitis

作者：宁海燕梁斌梁扬师

英文作者：

单位：571100海口市第四人民医院口腔科（宁海燕、梁扬师）；570311海口，海南省人民医院口腔科（梁斌）

英文单位：

关键词：慢性牙周炎；西帕依固龈液；复方硼砂含漱液；牙周指标；炎性反应；氧化应激反应

英文关键词：

• 摘要：

• 【摘要】目的    探讨西帕依固龈液对慢性牙周炎患者牙周指标和龈沟液中细胞因子的影响。方法    选择2015年5月至2016年5月在海口市第四人民医院接受治疗的慢性牙周炎患者72例为研究对象，采用随机双盲法分为对照组与观察组，各36例。2组患者均接受牙周基础治疗，对照组在此基础上使用复方硼砂含漱液治疗，而观察组在牙周基础治疗的基础上使用西帕依固龈液治疗，2组均连续治疗14 d。比较2组患者治疗前后牙周探诊深度（PD）、龈沟出血指数（SBI）、临床附着水平（CAL）、牙菌斑指数（PLI），龈沟液中高敏C反应蛋白（hs-CRP）、肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）和IL-8水平及血清超氧化物歧化酶（SOD）、丙二醛、谷胱甘肽过氧化物酶（GSH-Px）水平。结果    治疗前2组患者各项评价指标间差异均无统计学意义（均P＞0.05）。治疗后2组患者的PD、SBI、CAL和PLI均明显小于治疗前，且观察组明显小于对照组［（2.67±0.13）mm比（4.23±0.19）mm、（0.88±0.05）比（1.35±0.14）、（2.18±0.17）mm比（3.34±0.13）mm、（1.02±0.05）比（1.61±0.08）］（均P＜0.001）；治疗后对照组患者龈沟液中hs-CRP、IL-6和IL-8水平均明显低于治疗前，观察组患者龈沟液中hs-CRP、TNF-α、IL-6和IL-8水平均明显低于治疗前，且均明显低于对照组（均P＜0.001）；治疗后2组患者的血清SOD和GSH-Px水平均高于治疗前，丙二醛水平低于治疗前，且观察组患者的血清SOD和GSH-Px水平均高于对照组，丙二醛水平低于对照组（均P＜0.001）。结论    西帕依固龈液辅助治疗慢性牙周炎能够改善牙周指标，降低龈沟液中细胞因子水平，减轻炎性反应和氧化应激反应，疗效优于复方硼砂含漱液。

• 【Abstract】Objective    To investigate the effect of Xipayi mouth rinse on periodontal indexes and cytokines in gingival crevicular fluid in patients with chronic periodontitis. Methods    A total of 72 patients with chronic periodontitis admitted to the Fourth People′s Hospital of Haikou from May 2015 to May 2016 were randomly divided into control group(n=36) and observation group(n=36). The control group had compound borax mouth rinse and the observation group had Xipayi mouth rinse on the basis of basic periodontal treatment for 14 days. Periodontal probing depth(PD), sulcular bleeding index(SBI), clinical attachment level(CAL), dental plaque index(PLI), levels of hypersensitive C-reactive protein(hs-CRP), tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and IL-8 in gingival crevicular fluid, levels of serum superoxide dismutase(SOD), malondialdehyde(MDA) and glutathione peroxidase(GSH-Px) were analyzed. Results    There was no significant difference of these indicators between groups before treatment(P＞0.05). After treatment, PD, SBI, CAL and PLI significantly decreased and they were lower in observation group than those in control group［（2.67±0.13）mm vs （4.23±0.19）mm,（0.88±0.05） vs （1.35±0.14）, （2.18±0.17）mm vs （3.34±0.13）mm, （1.02±0.05） vs （1.61±0.08）］(all P＜0.001). After treatment, levels of hs-CRP, IL-6 and IL-8 in gingival crevicular fluid in control group were significantly lower than those before treatment; levels of hs-CRP, TNF-α, IL-6 and IL-8 in gingival crevicular fluid in observation group were significantly lower than those before treatment and those in control group(all P＜0.001). After treatment, serum levels of SOD and GSH-Px were higher and MDA was lower than those before treatment; the levels of SOD and GSH-Px in observation group were higher and MDA was lower than those in control group(all P＜0.001). Conclusion    Adjuvant treatment of chronic periodontitis with Xipayi mouth rinse can improve the periodontal status, reduce cytokines in gingival crevicular fluid, alleviate inflammation and oxidative stress; the therapeutic effect is better than that of compound borax mouth rinse.