2021 年第 5 期 第 16 卷

肺血栓栓塞症规律抗凝治疗后复发与患者ABO血型的关系

Association of ABO blood group with recurrence of pulmonary thromboembolism in patients after regular anticoagulation

作者：郭伟1焦建2肖瑶1刘泽英1刘双1谢江1

英文作者：Guo Wei1 Jiao Jian2 Xiao Yao1 Liu Zeying1 Liu Shuang1 Xie Jiang1

单位：1首都医科大学附属北京安贞医院呼吸与危重症医学科100029；2首都医科大学附属北京安贞医院核医学科100029

英文单位：1Department of Respiratory and Critical Care Medicine Beijing Anzhen Hospital Capital Medical University Beijing 100029 China; 2Department of Nuclear Medicine Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

关键词：肺血栓栓塞症；复发；O血型

英文关键词：Pulmonarythromboembolism;Recurrence;Obloodtype

• 摘要：

• 目的 探讨肺血栓栓塞症（PTE）规律抗凝治疗至少3个月后复发与患者ABO血型的关系。方法 回顾性分析2008年1月至2019年12月于首都医科大学附属北京安贞医院住院治疗的287例急性PTE患者的临床资料，根据PTE复发情况分为未复发组（147例）和复发组（140例）。收集患者首次就诊时的一般资料。比较2组暂时性危险因素比例、危险分层比例、治疗情况及ABO血型分布情况。结果 2组患者性别、年龄、身高、体质量、吸烟史及饮酒史比较，差异均无统计学意义(均P＞0.05)，复发组体重指数≥30.00 kg/m2比例低于未复发组，差异有统计学意义(P＜0.05)。复发组合并高血压、高脂血症比例均低于未复发组(均P＜0.05)。2组其他合并疾病比例比较，差异均无统计学意义(均P＞0.05)。复发组暂时性危险因素比例低于未复发组［5.7%（8/140）比20.4%（30/147）］，差异有统计学意义(P＜0.001)。2组危险分层、起始溶栓治疗比例及抗凝疗程比较，差异均无统计学意义(均P＞0.05)。复发组O型血比例低于未复发组［15.7%（22/140）比34.0%（50/147）］，差异有统计学意义(P＜0.001)，且复发组中A型血比例最高［40.7%（57/140）］。结论 规律抗凝治疗至少3个月后，O型血患者PTE复发风险较低。

• Objective To explore the association of ABO blood group with the recurrence of pulmonary thromboembolism (PTE) in patients after regular anticoagulation for 3 months at least. Methods From January 2008 to December 2019, clinical data of 287 patients with acute PTE who hospitalized in Beijing Anzhen Hospital, Capital Medical University were retrospectively analyzed. According to recurrence of PTE, they were divided into non-recurrence group(147 cases) and recurrence group(140 cases). General data of the patients at their first visit were collected. The transient risk factors rate, risk stratification rate, treatment and ABO blood group distribution were compared between the two groups. Results There were no significant differences in gender, age, height, body mass, smoking history and alcohol history between the two groups(all P>0.05). The rate of body mass index≥30.00 kg/m2 in recurrence group was lower than that in non-recurrence group(P<0.05). The rates of hypertension and hyperlipidemia in recurrence group were lower than those in non-recurrence group(both P<0.05). There were no significant differences in the rates of other co-morbidity between the two groups(all P>0.05). The transient risk factors rate in recurrence group was lower than that in non-recurrence group［5.7%(8/140) vs 20.4%(30/147)］(P<0.001). There were no significant differences in the rates of risk stratification and initial thrombolytic therapy, and course of anticoagulation between the two groups(all P>0.05). The rate of O blood type in recurrence group was lower than that in non-recurrence group［15.7%(22/140) vs 34.0%(50/147)］(P<0.001), and the rate of A blood type was the highest in recurrence group［40.7%(57/140)］. Conclusion Patients with O blood type have a low risk of recurrent PTE after regular anticoagulant therapy for 3 months at least.