2022 年第 7 期 第 17 卷

单核细胞/高密度脂蛋白胆固醇比值与急性冠状动脉综合征患者冠状动脉SYNTAX评分的相关性分析

Relationship between the monocyte/high-density lipoprotein cholesterol ratio and coronary SYNTAX score in patients with acute coronary syndrome

作者：葛小明1兰永昊2周玉杰1王志坚1刘巍2

英文作者：Ge Xiaoming1 Lan Yonghao2 Zhou Yujie1 Wang Zhijian1 Liu Wei2

单位：1首都医科大学附属北京安贞医院心内科北京市心肺血管疾病研究所，北京100029；2北京积水潭医院心内科，北京100035

英文单位：1Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vassel Diseases Beijing 100029 China; 2Department of Cardiology Beijing Jishuitan Hospital Beijing 100035 China

关键词：急性冠状动脉综合征；单核细胞；高密度脂蛋白胆固醇；冠状动脉SYNTAX评分

英文关键词：Acutecoronarysyndrome;Monocyte;High-densitylipoproteincholesterol;CoronarySYNTAXscore

• 摘要：

• 目的 探究行经皮冠状动脉介入（PCI）治疗的急性冠状动脉综合征（ACS）患者单核细胞/高密度脂蛋白胆固醇比值(MHR)与冠状动脉SYNTAX评分的相关性。方法 回顾性分析2017年6—9月在首都医科大学附属北京安贞医院接受PCI治疗的成年ACS患者的临床资料。每例患者的SYNTAX评分由专业的心内科医师进行评估，＜23分为低分组，≥23分为高分组。分析MHR与SYNTAX评分的相关性。结果 本研究纳入732例患者，其中低分组患者424例、高分组患者308例。单因素线性回归分析结果 示MHR与SYNTAX评分呈显著正相关（β值=0.236，95%置信区间：0.090~0.382），单因素Logistic回归分析结果显示MHR与高SYNTAX评分显著相关（比值比=1.052,95%置信区间：1.023~1.082），且在校正其他混杂因素后仍显著相关（均P＜0.05）。限制性立方样条图显示以MHR=7.6为参考值时，MHR与高SYNTAX评分呈现单调性正相关。亚组分析结果显示,在年龄<60岁、男性、不吸烟、高血压、非高血压、血脂异常人群中，MHR与SYNTAX评分均呈现显著正相关（均P＜0.05）。结论 接受PCI的ACS患者MHR与SYNTAX评分呈正相关。

• Objective To investigate the relationship between monocyte/high-density lipoprotein cholesterol ratio (MHR) and coronary SYNTAX score in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). MethodClinical data of adult ACS patients undergoing PCI were retrospectively analyzed who were admitted to Beijing Anzhen Hospital, Capital Medical University from June to September 2017. SYNTAX score of patients was evaluated by cardiologists, and patients were divided into low-score group (SYNTAX score <23) and high-score group (SYNTAX score≥23). The relationship between MHR and SYNTAX score was analyzed. Results Totally 732 patients were enrolled in the study, including 424 patients in low-score group and 308 patients in high-score group. The univariate linear regression analysis showed a positive correlation between MHR and SYNTAX score (β value=0.236, 95% confidence interval:0.090-0.382), the univariate Logistic regression analysis also showed that MHR was associated with the high SYNTAX score (odds ratio=1.052, 95% confidence interval:1.023-1.082), and those were still significantly correlated after adjusting for other confounding factors (all P<0.05). Restricted cubic spine showed that MHR was positively correlated with high SYNTAX score when MHR equalled 7.6. Subgroup analysis showed that MHR was positively correlated with SYNTAX score in the age<60 years, male, non-smoking, hypertension or non-hypertension, dyslipidemia patients (all P<0.05). Conclusion MHR is positively associated with SYNTAX score in ACS patients undergoing PCI.