2023 年第 5 期 第 18 卷

基于超声斑点追踪技术对心房颤动患者血脂水平与左心房时相功能相关性的研究

Study on the correlation between blood lipid level and left atrial phase function in patients with atrial fibrillation based on ultrasonic speckle tracking technology

作者：张苗苗1张璐2邓爱云2

英文作者：Zhang Miaomiao1 Zhang Lu2 Deng Aiyun2

单位：1兰州大学第一临床医学院，兰州730000；2兰州大学第一医院心内科彩超室，兰州730000 通信作者：邓爱云，Email:540218961@qq.com

英文单位：1The First School of Clinical Medicine of Lanzhou University Lanzhou 730000 China; 2Department of Cardiology and Ultrasound the First Hospital of Lanzhou University Lanzhou 730000 China

关键词：心房颤动；左心房时相功能；血脂；低密度脂蛋白

英文关键词：

• 摘要：

• 目的 基于超声斑点追踪技术探讨心房颤动患者血脂水平与左心房时相功能的相关性。方法 纳入2021年6月至2022年6月于兰州大学第一医院心内科住院的心房颤动患者86例，根据低密度脂蛋白胆固醇（LDL-C）水平将LDL-C＜2.86 mmol/L患者纳入LDL-C减低组（56例），其余患者纳入非LDL-C减低组（30例）。应用斑点追踪技术获得患者左心房时相应变参数。比较2组患者血脂水平差异并分析血脂水平与左心房时相功能的相关性。结果  LDL-C减低组左心房前后径(LAD)、左心房最大容积（LAVmax）、左心房最小容积（LAVmin）均大于非LDL-C减低组，左心房总排空分数（LAtEF）、左心房储器应变率（pLASRr）、左心房管道应变率（pLASRcd）、左心房泵应变率（pLASRct）均小于非LDL-C减低组（均P＜0.05）。多元线性回归分析结果显示，LDL-C、高密度脂蛋白胆固醇与pLASRr呈正相关（P=0.004、0.019）；LDL-C与pLASRcd呈正相关（P=0.004），年龄与pLASRcd呈负相关（P=0.043）；LDL-C、载脂蛋白A1与pLASRct呈正相关（P=0.028、0.048）。结论   心房颤动患者左心房时相功能与LDL-C具有相关性，LDL-C水平减低在一定程度上可加重心房颤动患者左心房时相功能的损害。

• Objective  To explore the correlation between blood lipid level and left atrial phase function in patients with atrial fibrillation based on ultrasonic speckle tracking technology. Methods From June 2021 to June 2022, 86 patients with atrial fibrillation admitted to Department of Cardiology, the First Hospital of Lanzhou University were included. According to the level of low-density lipoprotein cholesterol(LDL-C), patients with LDL-C＜2.86 mmol/L were divided into LDL-C reduction group (56 cases), and the rest patients were divided into non LDL-C reduction group (30 cases). The corresponding parameters of left atrial phase were obtained by speckle tracking technology, and the differences of blood lipid level in different groups and the correlation between blood lipid level and left atrial phase function in patients with atrial fibrillation were analyzed. ResultsThe left atrium diameter (LAD), left atrium maximum volume (LAVmax), and left atrium minimum volume (LAVmin) in the LDL-C reduction group were greater than those in the non LDL-C reduction group, while the left atrium total emptying fraction (LAtEF), left atrial peak strain rate during reservoir phases (pLASRr), left atrium peak strain rate during the conduit phases (pLASRcd), and left atrium peak strain rate during the contraction phase (pLASRct) were lower than those in the non LDL-C reduction group (all P＜0.05). Multiple linear regression analysis showed that LDL-C, high-density lipoprotein cholesterol were positively correlated with pLASRr (P=0.004, 0.019); LDL-C was positively correlated with pLASRcd (P=0.004), while age was negatively correlated with pLASRcd (P=0.043); LDL-C and apolipoprotein A1 were positively correlated with pLASRct (P=0.028, 0.048). Conclusion The left atrial phase function in patients with atrial fibrillation is related to the level of LDL-C. The decrease of LDL-C level can aggravate the damage of left atrial phase function in patients with atrial fibrillation to a certain extent.