2024 年第 6 期 第 0 卷

临床前期类风湿关节炎研究进展

Research progress of preclinical rheumatoid arthritis

作者：郭耀佳1李桓1李松伟2

英文作者：Guo Yaojia1 Li Huan1 Li Songwei2

单位：1河南中医药大学第一附属医院风湿免疫科，郑州450000；2河南省中医院风湿免疫科，郑州450000

英文单位：1Department of Rheumatology and Immunology the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000 China; 2Department of Rheumatology and Immunology Henan Province Hospital of Traditional Chinese Medicine Zhengzhou 450000 China

关键词：类风湿关节炎；临床前期类风湿关节炎；危险因素

英文关键词：Rheumatoidarthritis;Preclinicalrheumatoidarthritis;Riskfactors

• 摘要：

• 类风湿关节炎(RA)的发展是一个多步骤的过程，该病在临床关节炎症状出现以前就已经活跃。临床前期类风湿关节炎（Pre-RA）是指从疾病开始到临床关节炎出现之前的疾病发展时期，已证实临床前期干预可降低RA严重程度、延迟RA发作的时间。本综述旨在探讨Pre-RA中发展为RA的危险因素，通过对RA高危人群进行适当临床前期干预，以期达到最佳治疗效果。

• The development of rheumatoid arthritis (RA) is a multi-step process and the disease is active before clinical arthritic symptoms appear. Preclinical rheumatoid arthritis (Pre-RA) refers to the period of disease development from the onset of the disease to the onset of clinical arthritis. It has been demonstrated that preclinical intervention can reduce the severity of RA and delay the onset of RA. The purpose of this review is to explore the risk factors for developing into RA from Pre-RA, so as to achieve the best therapeutic effect through appropriate pre-clinical intervention in high-risk groups of RA.