2017 年第 12 期 第 12 卷

地佐辛注射液治疗急性结石性肾绞痛的临床效果

作者：杨雍吕汝琦刘纪宁冷晓辉

英文作者：

单位：621000四川省绵阳市中心医院急诊科

英文单位：

关键词：急性肾绞痛；地佐辛；盐酸哌替啶注射液

英文关键词：

• 摘要：

• 目的    观察地佐辛注射液治疗急性结石性肾绞痛的临床效果及安全性。方法    选择 2015年 6月至2016年9月在四川省绵阳市中心医院急诊科就诊的输尿管结石性肾绞痛患者286例。所有患者完全随机分为对照组和观察组，各143例。对照组患者给予盐酸哌替啶注射液50 mg肌内注射，观察组患者给予地佐辛注射液5 mg肌内注射。比较2组患者治疗前和治疗后30、60 min疼痛口述分级评分法（VRS）评级、疼痛视觉模拟量表（VAS）评分、总有效率和不良反应情况。结果    2组间治疗前和治疗后30、60 min VRS评级比较，差异均无统计学意义（均P＞0.05）。2组内治疗后30、60 min VRS评级低于治疗前［对照组：（1.7±0.4）、（1.6±0.3）级比（2.4±0.7）级；观察组：（1.7±0.4）、（1.5±0.5）级比（2.5±0.7）级］，差异均有统计学意义（均P＜0.05）。2组间治疗前和治疗后30、60 min VAS评分比较，差异均无统计学意义（均P＞0.05）。2组内治疗后30、60 min VAS评分低于治疗前［对照组：（2.7±0.8）、（2.6±0.5）分比（7.7±0.7）分；观察组：（3.1±0.6）、（2.8±0.6）分比（7.6±0.7）分］，差异均有统计学意义（均P＜0.05）。观察组总有效率与对照组比较，差异无统计学意义（P＞0.05）。观察组不良反应发生率低于对照组［4.9%(7/143)比20.3%（29/143）］，差异有统计学意义（P＜0.05）。结论    地佐辛注射液治疗急性结石性肾绞痛有较好的镇痛效果，且不良反应少。

• Clinical effect of dezocine injection on acute calculous renal colic

  Yang Yong, Lyu Ruqi, Liu Jining, Leng Xiaohui

  Department of Emergency, Mianyang Central Hospital, Sichuan Province, Mianyang 621000, China

  Corresponding author: Lyu Ruqi, Email: 877979182@qq.com

  【Abstract】Objective    To analyze the clinical curative effect and safety of dezocine injection on acute calculous renal colic. Methods    Totally 286 patients with ureteral calculous renal colic in the Department of Emergency of Mianyang Central Hospital in Sichuan Province from June 2015 to September 2016 were randomly divided into control group and observation group, with 143 cases in each group. The control group was treated with 50 mg pethidine hydrochloride intramuscular injection; the observation group patients was treated with 5 mg dezocine intramuscular injection. Grade of the Vertal Rating Scale(VRS), score of the Visual Analogue Scale(VAS) for pain, the total effective rate and adverse reactions were analyzed. Results    The VRS grade had no significant difference between groups before and 30, 60 min after treatment（P＞0.05）. The VRS grade 30 and 60 min after treatment was significantly lower than that before treatment［control group: （1.7±0.4）,（1.6±0.3） vs （2.4±0.7）; observation group: （1.7±0.4）,（1.5±0.5） vs （2.5±0.7）］（P＜0.05）. The VAS score had no significant difference between groups before and 30, 60 min after treatment（P＞0.05）. The VAS score 30 and 60 min after treatment was significantly lower than that before treatment［control group: （2.7±0.8）,（2.6±0.5）points vs （7.7±0.7）points; observation group: （3.1±0.6）,（2.8±0.6）points vs （7.6±0.7）points］（P＜0.05）. The total effective rate had no significant difference between groups（P＞0.05）. The incidence of adverse reactions in observation group was significantly lower than that in control group［4.9%（7/143） vs 20.3%（29/143）］（P＜0.05）. Conclusion    Dezocine injection has a good and safe analgesic effect on acute calculous renal colic.

  【Key words】Acute renal colic;Dezocine;Pethidine hydrochloride injection