2018 年第 2 期 第 13 卷

金刚烷胺治疗创伤性颅脑损伤的临床应用及作用机制的研究进展

作者：苏清岩吴佳玉彭慧平卢晓欣

英文作者：

单位：350025南京军区福州总医院（福建中医药大学教学医院）康复医学科

英文单位：

关键词：创伤性颅脑损伤；金刚烷胺；临床应用；作用机制

英文关键词：

• 摘要：

• 创伤性颅脑损伤是一种常见的多发病，近年发病呈增长趋势。金刚烷胺除了具有抗病毒、抗帕金森作用外，目前有较多的研究报道金刚烷胺可应用于创伤性颅脑损伤后的治疗，包括意识障碍、认知功能与行为等。本文对金刚烷胺治疗创伤性颅脑损伤的临床应用及作用机制进行归纳总结，为进一步的研究提供依据。

• Research progress of amantadine in traumatic brain injury

  Su Qingyan, Wu Jiayu, Peng Huiping, Lu Xiaoxin

  Department of Rehabilitation Medicine, Fuzhou General Hospital of Nanjing Military Command (the Teaching Hospital of Fujian University of Traditional Chinese Medicine), Fuzhou 350025, China

  Corresponding author: Peng Huiping, Email: 361140072@qq.com

  【Abstract】Traumatic brain injury is a common and frequent disease. Amantadine is generally used for its antiviral and anti-Parkinson effects; recent studies have reported the curative effect of amantadine on conscious disturbance, cognitive impairment and behavior disorder in patients with traumatic brain injury. This article summarized clinical application and mechanism of amantadine in traumatic brain injury.

  【Key words】Traumatic brain injury；Amantadine；Clinical application；Mechanism of action

  【Fund program】Natural Science Foundation of Fujian Province（2016J01584）