2018 年第 3 期 第 13 卷

2型糖尿病患者发生阿司匹林所致胃肠道出血的危险因素分析

Risk factors of gastrointestinal bleeding caused by aspirin in patients with type 2 diabetes mellitus    

作者：刘俊伟李红梅邓爱民

英文作者：

单位：510010广州军区广州总医院内分泌科

英文单位：

关键词：

英文关键词：

• 摘要：

• 目的    探讨2型糖尿病患者发生阿司匹林所致胃肠道出血的危险因素。方法    回顾性分析2011年 1月1日至2017年6月31日广州军区广州总医院内分泌科1 087例住院2型糖尿病患者的病历资料，均持续口服阿司匹林肠溶片100 mg/次，1次/d，服药时间≥7 d。发生胃肠道出血事件的患者归为出血组（152例），其余患者为非出血组（935例）。详细记录患者的各项临床资料并进行组间单因素分析和Logistic回归分析。结果    单因素分析结果显示，出血组患者年龄、吸烟、饮酒、消化道疾病的构成比明显高于非出血组［（70±11）岁比（65±12）岁、74.3%（113/152）比63.4%（593/935）、40.8%（62/152）比25.8%（241/935）、18.4%（28/152）比7.8%（73/935）］，差异均有统计学意义（均P＜0.05）。Logistic回归分析结果显示，年龄（比值比＝2.559，P＝0.030，95%置信区间：1.093～5.989）和饮酒（比值比＝2.039，P＝0.023，95%置信区间：1.102～3.771）是2型糖尿病患者发生阿司匹林所致胃肠道出血的危险因素。结论    高龄及长期饮酒是2型糖尿病患者发生阿司匹林所致胃肠道出血的高危因素。

• Objective    To analyze the risk factors of gastrointestinal bleeding caused by aspirin in patients with type 2 diabetes mellitus. Methods    Totally 1 087 type 2 diabetic patients admitted from January 1st, 2011 to June 31st, 2017 in General Hospital of Guangzhou Military Command of People′s Liberation Army were retrospectively analyzed; all patients took bayaspirin enteric-coated tablets 100 mg/time, 1 time/d. Gastrointestinal bleeding occurred in 152 cases（bleeding group）and 935 cases were non-bleeding group. Related indicators of aspirin-induced gastrointestinal bleeding were analyzed by single-factor test and logistic regression test. Results    Age, smoking ratio, alcohol-drinking ratio and gastrointestinal disease ratio in bleeding group were significantly higher than those in non-bleeding group［（70±11）years vs （65±12）years, 74.3%（113/152） vs 63.4%（593/935）, 40.8%（62/152） vs 25.8%（241/935）, 18.4%（28/152） vs 7.8%（73/935）］（P＜0.05）. Logistic regression showed that advanced age（odds ratio＝2.559, P＝0.030, 95% confidence interval: 1.093-5.989） and alcohol-drinking（odds ratio＝2.039, P＝0.023, 95% confidence interval: 1.102-3.771） were risk factors of aspirin-induced gastrointestinal bleeding. Conclusion    Advanced age and alcohol-drinking are risk factors of gastrointestinal bleeding caused by aspirin in patients with type 2 diabetes mellitus.