2018 年第 11 期 第 13 卷

老年人重症肌无力研究进展

Research progress of myasthenia gravis in the elderly

作者：刘书平卢祖能柳胤姚嘉嘉

英文作者：

单位：430060武汉大学人民医院神经内科

英文单位：

关键词：重症肌无力；胆碱酯酶抑制剂；免疫抑制剂

英文关键词：

• 摘要：

• 【摘要】重症肌无力(MG)是一种神经肌肉传递障碍的获得性自身免疫性疾病，主要发生于中青年，50岁以后很少出现新发病例。但随着人口的老龄化和诊断技术的不断提高，老年人MG发病率逐渐升高。老年人的免疫功能较弱，且常合并其他疾病（如心脑血管疾病、呼吸系统疾病、肿瘤等）,这会加重或掩盖MG病情,给临床诊断和治疗带来困难。关于老年人MG临床特点以及对药物和手术治疗反应的研究结果不尽相同，正确认识MG的临床特点有助于临床医生及早做出正确诊断，提高疗效并改善预后。

• 【Abstract】Myasthenia gravis(MG) is an acquired autoimmune disease caused by neuromuscular transmission dysfunction. It mainly occurs in young and middle-aged people. However, with the growing population aging and continuous improvement of diagnostic technology, the incidence of MG is increasing in elderly people. The elderly are more vulnerable to cardiovascular and cerebrovascular diseases, respiratory diseases and tumors, which may aggravate or cover MG condition, causing difficulties in clinical diagnosis and treatment. This paper summarized the research progress of immunologic and clinical features, drugs and surgical treatments of MG in elderly patients.