2019 年第 3 期 第 14 卷

阿司匹林肠溶片联合抗菌药物治疗急性附睾炎的临床效果

Clinical effect of aspirin enteric-coated tablets combined with antibacterials on acute epididymitis

作者：杨晓峰田涛王倩倩王新丽高建国

英文作者：

单位：277100山东省枣庄市立医院泌尿外科

英文单位：

关键词：急性附睾炎；头孢曲松钠；阿司匹林肠溶片；精子质量

英文关键词：

• 摘要：

• 【摘要】目的    评价阿司匹林肠溶片联合抗菌药物治疗急性附睾炎的临床效果。方法    选择2012年1月至2017年1月在山东省枣庄市立医院确诊为急性附睾炎的患者260例，按照就诊顺序随机分为对照组和观察组，各130例。对照组患者单用头孢曲松钠注射液治疗，观察组患者采用头孢曲松钠联合阿司匹林肠溶片治疗。比较用药2周时治疗有效率，治疗2、4周时附睾肿块有效缩小率，治疗1、2周时疼痛有效控制率及治疗4周时患者的精子质量。结果    治疗2周时，观察组治疗有效率高于对照组［94.6%（123/130）比69.2%（90/130）］，差异有统计学意义（P<0.05）。治疗4周时观察组附睾肿块有效缩小率高于对照组［96.2%(125/130)比72.3%(94/130)］，差异有统计学意义（P<0.05）。治疗1周、2周时观察组患者疼痛控制有效率高于对照组［80.8%(105/130)比30.8%(40/130)、99.2%(129/130)比53.8%(70/130)］，差异均有统计学意义(均P<0.05)。治疗4周时观察组精子活动率、精子浓度和a级+b级精子比例高于对照组［(85±6)%比(63±4)%、(35.1±1.8)×106/ml比(25.2±2.4)×106/ml、(61±5)%比(50±3)%］，差异均有统计学意义(均P<0.05)。结论    阿司匹林肠溶片联合抗菌药物治疗急性附睾炎可改善临床疗效，明显提高精子质量。

• 【Abstract】Objective    To analyze the clinical effect of aspirin enteric-coated tablets combined with antibiotics on acute epididymitis. Methods    Totally 260 patients diagnosed of acute epididymitis from January 2012 to January 2017 in Zaozhuang Municipal Hospital of Shandong Province were randomly divided into control group and observation group, with 130 cases in each group. The control group was treated with ceftriaxone sodium injection and the observation group was treated with ceftriaxone sodium plus aspirin enteric-coated tablets. Therapeutic effectiveness was assessed 2 weeks after medication; reduction rate of epididymal mass was measured 2 and 4 weeks after treatment; control rate of pain was assessed 1 and 2 weeks after treatment; sperm quality was evaluated 4 weeks after treatment. Results    The 2-week effective rate in observation group was significantly higher than that in control group［94.6%（123/130） vs 69.2%（90/130）］（P<0.05）. At 4 weeks after treatment, reduction rate of epididymal mass in observation group was significantly higher than that in control group［96.2%(125/130) vs 72.3%(94/130)］（P<0.05）. Control rate of pain in observation group was significantly higher than that in control group at 1 and 2 weeks after treatment［80.8%(105/130) vs 30.8%(40/130), 99.2%(129/130) vs 53.8%(70/130)］（both P<0.05）. At 4 weeks after treatment, sperm motility rate, sperm concentration and grade a+b sperm ratio in observation group were significantly higher than those in control group［(85±6)% vs (63±4)%, (35.1±1.8)×106/ml vs (25.2±2.4)×106/ml, (61±5)% vs (50±3)%］（all P<0.05）. Conclusion    Aspirin enteric-coated tablets combined with antibiotics is effective in treating acute epididymitis and improving sperm quality.