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2019 年第 4 期 第 14 卷

FIZZ1和白细胞介素4及γ-干扰素在弥漫性间质性肺疾病中的表达及对患者临床转归的影响

Expressions of found in inflammatory zone 1, interleukin-4 and γ-interferon in diffuse interstitial lung disease and the effect on clinical outcomes

作者:廖洋江宇罗春程胜

英文作者:

单位:401331重庆医科大学附属大学城医院呼吸中心

英文单位:

关键词:弥漫性间质性肺疾病;FIZZ1;白细胞介素4;γ-干扰素;临床转归

英文关键词:

  • 摘要:
  • 【摘要】目的    探讨FIZZ1、白细胞介素4(IL-4)、γ-干扰素在弥漫性间质性肺疾病(DILD)中的表达及对患者临床转归的影响。方法    前瞻性选取2011年1—12月于重庆医科大学附属大学城医院首次确诊为DILD的患者37例,分别于治疗前、治疗3个月后检测患者肺组织中FIZZ1蛋白、FIZZ1 mRNA及肺泡灌洗液中白细胞介素4(IL-4)和γ-干扰素的表达情况,并根据患者的疾病转归将其分为治疗有效组和治疗无效组。结果    治疗3个月后27例有效(治疗有效组),10例无效(治疗无效组)。治疗后,治疗有效组肺组织中FIZZ1蛋白、FIZZ1 mRNA和肺泡灌洗液中IL-4水平明显低于治疗无效组[(0.49±0.12)比(0.71±0.18)、(0.68±0.19)比(0.92±0.23)、(45±8)ng/L比(105±9)ng/L],γ-干扰素水平明显高于治疗无效组[(28±5)ng/L比(15±3)ng/L](均P<0.05)。治疗前患者FIZZ1蛋白、FIZZ1 mRNA与IL-4均呈正相关(r=0.637,P<0.001; r=0.624,P<0.001),与γ-干扰素均呈负相关(r=-0.529,P<0.001; r=-0.511,P<0.001)。结论    FIZZ1、IL-4、γ-干扰素在DILD中均有表达,且彼此存在相互作用。不同疾病转归患者的3种因子表达水平存在差异,通过探索有效方法抑制或调控其表达,将有效抑制早期肺纤维化形成,阻止肺功能减退,提高患者生活质量,同时为疾病转归、预后监测提供新的生物学标志物。

  • 【Abstract】Objective    To explore the expressions of found in inflammatory zone 1(FIZZ1), interleukin-4(IL-4) and γ-interferon(γ-IFN) in diffuse interstitial lung disease(DILD) and the effect on clinical outcomes. Methods    A total of 37 patients diagnosed of DILD in University-Town Hospital of Chongqing Medical University from January to December 2011 were prospectively enrolled. Expressions of FIZZ1 protein and FIZZ1 mRNA in lung tissue, expressions of IL-4 and γ-IFN in bronchoalveolar lavage fluid were detected before and 3 months after treatment. The patients were divided into effective group and ineffective group according to the clinical outcomes. Results    All patients were followed up for 3 months; 27 cases were improved(effective group) and 10 cases were ineffective(ineffective group). After treatment, expression levels of FIZZ1 protein, FIZZ1 mRNA and IL-4 in the effective group were significantly lower than those in the ineffective group[(0.49±0.12) vs (0.71±0.18), (0.68±0.19) vs (0.92±0.23), (45±8)ng/L vs (105±9)ng/L]; expression level of γ-IFN in the effective group was significantly higher than that in the ineffective group[(28±5)ng/L vs (15±3)ng/L](P<0.05). Before treatment, FIZZ1 protein and mRNA expressions were positively correlated with IL-4 level(r=0.637, P<0.001; r=0.624, P<0.001) and they were negatively correlated with γ-IFN level(r=-0.529, P<0.001; r=-0.511, P<0.001). Conclusions    There an interaction among expressions of FIZZ1, IL-4 and γ-IFN in patients with DILD and the expression levels are associated with clinical outcomes. Down-regulation of FIZZ1, IL-4, γ-IFN can inhibit early pulmonary fibrosis, restrain pulmonary dysfunction, improve quality of life; these factors may be new biomarkers for prognostic prediction of DILD.

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