2019 年第 4 期 第 14 卷

卵圆孔未闭与阻塞性睡眠呼吸暂停关系的研究进展

Research progress of the relation between patent foramen ovale and obstructive sleep apnoea

作者：付强郭彩霞

英文作者：

单位：100070首都医科大学附属北京天坛医院心脏及大血管病中心

英文单位：

关键词：卵圆孔未闭；阻塞性睡眠呼吸暂停

英文关键词：

• 摘要：

• 【摘要】阻塞性睡眠呼吸暂停（OSA）和卵圆孔未闭（PFO）在普通人群中具有较高的发病率，二者相互关联，互相影响。OSA时右心压力升高，促进PFO开放，而心房间的右向左分流导致伴有PFO的OSA患者血氧饱和度明显下降，使OSA患者脑卒中危险增加。尽管经导管PFO封堵术的作用和疗效尚不确定，但将来可成为OSA患者预防缺血性卒中的治疗选择。

• 【Abstract】Prevalences of obstructive sleep apnoea(OSA) and patent foramen ovale(PFO) are high in common population and there is relation and interaction between them. Right atrial pressure increases during OSA and promotes PFO opening, right-to-left shunt leads to oxygen saturation reducing, which may be associated with high risk of stroke. Although the efficacy of PFO transcatheter closure remains uncertain, it becomes an alternative therapeutic choice to prevent ischemic stroke in patients with OSA.