设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 

主管单位:中华人民共和国   

国家卫生健康委员会

主办单位:中国医师协会
总编辑:
杨秋

编辑部主任:吴翔宇

邮发代号:80-528
定价:28.00元
全年:336.00元
Email:zgyy8888@163.com
电话(传真):010-64428528;
010-64456116(总编室)

                  

过刊目录

2019 年第 5 期 第 14 卷

沙库巴曲缬沙坦钠片对慢性心力衰竭患者的疗效及对神经内分泌激素活性的影响

Efficacy of sacubitril/valsartan sodium tablets in treatment of chronic heart failure and the effect on neuroendocrine hormone activity    

作者:董蕾田颖刘肆仁陆锐陈磊华明明

英文作者:

单位:100007北京市第六医院心内科

英文单位:

关键词:慢性心力衰竭;沙库巴曲缬沙坦钠片;神经内分泌激素

英文关键词:

  • 摘要:
  • 【摘要】目的    探讨沙库巴曲缬沙坦钠片对慢性心力衰竭患者的疗效及对神经内分泌激素活性的影响。方法    选取2017年11月至2018年10月在北京市第六医院就诊的慢性心力衰竭患者60例,按照随机数字表法分为观察组和对照组,各30例。对照组在一般治疗基础上加用缬沙坦胶囊治疗;观察组在一般治疗基础上加用沙库巴曲缬沙坦钠片治疗。比较2组临床疗效和治疗前及治疗12周后神经内分泌激素水平,包括血浆去甲肾上腺素、醛固酮和血管紧张素Ⅱ(Ang Ⅱ)。结果    治疗后,观察组总有效率明显高于对照组[83.3%(25/30)比53.3%(16/30)],差异有统计学意义(χ2=6.239,P=0.012)。治疗前,2组患者血浆去甲肾上腺素、醛固酮、Ang Ⅱ水平比较,差异均无统计学意义(均P>0.05)。治疗后,观察组血浆去甲肾上腺素、醛固酮、Ang Ⅱ水平均明显低于治疗前和对照组[(1 658±243)pmol/L比(2 387±368)、(2 060±289)pmol/L;(247±14)ng/L比(309±27)、(283±19)ng/L;(99±8)ng/L比(118±9)、(114±9)ng/L],差异均有统计学意义(均P<0.05)。结论    沙库巴曲缬沙坦钠片用于慢性心力衰竭的治疗能够有效改善症状,并抑制神经内分泌激素的过度激活。

  • 【Abstract】Objective    To investigate the therapeutic effect of sacubitril/valsartan sodium tablets on patients with chronic heart failure and the effect on neuroendocrine hormone activity. Methods    A total of 60 patients with chronic heart failure admitted to Beijing No.6 Hospital from November 2017 to October 2018 were randomly divided into observation group and control group, with 30 cases in each group. On the basis of routine treatment, the control group took valsartan capsules and the observation group took sacubitril/valsartan sodium tablets. Clinical efficacy and levels of plasma neuroendocrine hormones including norepinephrine, aldosterone and angiotensin Ⅱ(Ang Ⅱ) before and 12 weeks treatment were analyzed. Results    Total effective rate in observation group was significantly higher than that in control group[83.3%(25/30) vs 53.3%(16/30)](χ2=6.239,P=0.012). Before treatment, there was no significant difference of noradrenaline, aldosterone and Ang Ⅱ between groups(all P>0.05). After treatment, levels of noradrenaline, aldosterone and Ang Ⅱ in observation group were significantly lower than those in control group[(1 658±243)pmol/L vs (2 387±368),(2 060±289)pmol/L; (247±14)ng/L vs (309±27),(283±19)ng/L; (99±8)ng/L vs (118±9),(114±9)ng/L](all P<0.05).  Conclusion    Sacubitril/valsartan salium tablets can effectively improve clinical symptoms and inhibit the over-activation of neuroendocrine hormones in the treatment of chronic heart failure.

copyright 《中国医药》杂志编辑部
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层
电话:010-64456116 传真:010-64428528 邮编:100029 Email: zgyy8888@163.com
网址:www.chinamedicinej.com 京ICP备2020043099号-3

当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com。







安卓


苹果

关闭