2019 年第 5 期 第 14 卷

容积旋转调强放射治疗对脑胶质瘤的干预效果及对患者生活质量的影响

Therapeutic effect of volume-rotation intensity-modulated radiotherapy on glioma and the effect on quality of life

作者：顾国强熊敏荣孙云峰李清波

英文作者：

单位：313000浙江省湖州市第三人民医院放射科（顾国强、熊敏荣、孙云峰）；313000浙江省湖州市中心医院放疗科（李清波）

英文单位：

关键词：脑胶质瘤；容积旋转调强放射；生活质量

英文关键词：

• 摘要：

• 【摘要】目的    研究容积旋转调强放射治疗对脑胶质瘤的干预效果及对患者生活质量的影响。方法    选择2016年3月至2018年3月在浙江省湖州市第三人民医院诊治的脑胶质瘤患者65例为研究对象。通过随机数字表法分为观察组（33例）和对照组（32例）。对照组采用调强适形放射治疗，观察组采用容积旋转调强放射治疗。比较2组治疗后疗效、生活质量评分、中位生存期及不良反应发生情况。结果    治疗后，观察组总有效率高于对照组［90.9%（30/33）比62.5%（20/32）］，差异有统计学意义（P＜0.05）。治疗后，2组患者躯体功能、角色功能、情绪功能、社会功能、认知功能方面的生活质量评分均高于治疗前，且观察组高于对照组，差异均有统计学意义（均P＜0.05）。观察组患者中位生存期明显长于对照组［（18.4±3.3）个月比（14.2±2.1）个月］，差异有统计学意义（P<0.01）。治疗期间，观察组不良反应总发生率低于对照组［18.2%（6/33）比65.6%（21/32）］，差异有统计学意义（P<0.01）。结论    在脑胶质瘤患者中应用容积旋转调强放射治疗，疗效显著，可改善患者生活质量。

• 【Abstract】Objective    To explore the therapeutic effect of volume-rotation intensity-modulated radiotherapy on patients with glioma and the effect on quality of life. Methods    A total of 65 patients with glioma diagnosed in Huzhou Third People′s Hospital, Zhejiang Province, from March 2016 to March 2018 were randomly divided into observation group(33 cases) and control group(32 cases). The control group was treated with intensity-modulated conformal radiotherapy; the observation group was treated with volume-rotation intensity-modulated radiotherapy. Clinical efficacy, quality of life score, median survival and adverse reactions were analyzed. Results    After treatment, the total effective rate in observation group was significantly higher than that in control group［90.9%（30/33） vs 62.5%（20/32）］(P<0.05). Scores of physical function, role function, emotional function, social function and cognitive function were significantly improved after treatment in both groups and the scores in observation group were significantly higher than those in control group(all P<0.05). Median survival time in observation group was significantly longer than that in control group［(18.4±3.3)months vs (14.2±2.1)months］(P<0.01). Incidence of adverse reactions in observation group was significantly lower than that in control group［18.2%(6/33) vs 65.6%(21/32)］(P<0.01). Conclusion    Volume-rotation intensity-modulated radiotherapy is effective in the treatment of glioma and it can significantly improve the quality of life.