2020 年第 4 期 第 15 卷

慢性射血分数降低型心力衰竭的药物治疗进展

Progress in drug therapy of chronic heart failure with reduced ejection fraction

作者：孙浩楠1王志家1高玉霞1胡雪霄2杨清1

英文作者：Sun Haonan1 Wang Zhijia1 Gao Yuxia1 Hu Xuexiao2 Yang Qing1

单位：1天津医科大学总医院心内科300052；2河北北方学院附属第一医院神经内科，河北省张家口市075000

英文单位：1Department of Cardiology Tianjin Medical University General Hospital Tianjin 300052 China; 2Department of Neurology the First Affiliated Hospital of Hebei North University Hebei Province Zhangjiakou 075000 China

关键词：    慢性心力衰竭；药物；治疗

英文关键词：Chronicheartfailure；Medicine；Therapy

• 摘要：

• 【摘要】虽然近20年来心血管病病死率已明显下降，但慢性心力衰竭（CHF）作为心血管疾病的终末阶段仍是全球的主要死亡原因之一。随着人们对CHF发病机制的认识不断深入，射血分数降低型心力衰竭的药物治疗也取得了长足的进步，为提高CHF患者的生活质量带来了新希望。本综述对射血分数降低型心力衰竭的最新药物治疗进行一个简要总结，并根据病情及临床治疗的需求和临床证据之间的差距探讨未来的研究重点。

• 【Abstract】Over the past 20 years, there has been a significant decline in mortality rate of cardiovascular disease(CVD). As the end stage of CVD, chronic heart failure（CHF） remains a leading cause of mortality in the world. With deepening understanding of the pathogenesis of CHF, drug therapy of CHF with reduced ejection fraction（HFrEF） have made great strides, bringing new hope for improving quality of life in CHF patients. This paper reviewed the advances in novel drugs treating HFrEF and interpreted prospective research points based on the gaps between clinical evidence and practical demands.