2020 年第 4 期 第 15 卷

丙戊酸诱导的可逆性帕金森综合征和认知功能障碍研究进展

Research progress of reversible Parkinson syndrome and cognitive impairment induced by valproic acid

作者：齐彩云许二赫

英文作者：Qi Caiyun Xu Erhe

单位：首都医科大学宣武医院神经内科，北京100053

英文单位：Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China

关键词：帕金森综合征；丙戊酸；认知功能障碍；可逆性

英文关键词：Parkinsonsyndrome;Valproicacid;Cognitiveimapirment;Reversible

• 摘要：

• 【摘要】丙戊酸是一种抗癫药物，对部分性及全面性癫发作均具有较好的疗效。一些病例报告和系列研究报道，使用丙戊酸可引起可逆性帕金森综合征和认知能力下降，这种帕金森综合征对左旋多巴治疗无反应，但通常在停用丙戊酸后数周至数月内逆转。由于起病隐匿，症状不典型者容易被临床医师忽视，如果不及时识别及减停丙戊酸则存在延误诊断甚至导致功能丧失的可能性。国内相关文献报道较少，希望在此进行的相关病例回顾能引起广大临床医师的重视。

• 【Abstract】Valproic acid is an effective drug against partial and comprehensive epilepsy. Some cases and researches have reported reversible parkinsonism and cognitive decline in patients taking valproic acid, which showed no response to levodopa treatment but disappeared in several weeks or months after withdrawal. Due to the insidious onset and atypical manifestation, Parkinson syndrome and cognitive impairment induced by valproic acid can be easily ignored by clinical physicians.Delayed diagnosis can lead to long term adverse effect on patients and even severe functional incapacitation. We hope to bring it to the forefront by this case review.