2020 年第 5 期 第 15 卷

华蟾素胶囊联合放疗治疗晚期胰腺癌的临床效果观察

Clinical efficacy of Huachansu combined with radiotherapy in the treatment of advanced pancreatic cancer

作者：朱必胜;田红岸;舒诚荣;韩琦;肖秋菊

英文作者：Zhu Bisheng Tian Hong′an Shu Chengrong Han Qi Xiao Qiuju

单位：湖北省咸宁市中心医院湖北科技学院附属第一医院肿瘤科437100

英文单位：Department of Oncology Xianning Central Hospital the First Affiliated Hospital of Hubei University of Science and Technology Hubei Province Xianning 437100 China

关键词：晚期胰腺癌；华蟾素；放疗；生存率

英文关键词：Advancedpancreaticcancer；Huachansu；Radiotherapy；Survivalrate

• 摘要：

• 目的 探讨华蟾素胶囊联合放疗对晚期胰腺癌患者的疗效。方法 选择咸宁市中心医院2010年1月至2016年6月收治的82例晚期胰腺癌患者，按照随机数字表法分为观察组和对照组，各41例。对照组患者应用放疗治疗，观察组在对照组基础上联合华蟾素胶囊口服治疗，2组均以4周为1个疗程。比较2组患者治疗4个疗程后疗效、2年生存率及平均生存时间；统计2组治疗过程中出现的不良反应，包括胃肠道反应（恶心、呕吐）、肝肾功能损伤和骨髓抑制情况；根据汉化中文版癌症患者生活质量量表评价患者治疗前后的生活质量。结果 观察组治疗总有效率明显高于对照组［48.8%(20/41)比26.8%(11/41)］，2年生存率明显高于对照组［26.8%(11/41)比9.8%(4/41)］，且平均生存时间长于对照组［（10.2±2.2）个月比（8.1±1.7）个月］，差异均有统计学意义（均P＜0.05）。治疗期间，观察组胃肠道反应发生率明显低于对照组［17.1%(7/41)比36.6%(15/41)］，差异有统计学意义（P＜0.05）。治疗后，观察组患者各项生活质量评分均高于对照组，差异均有统计学意义（均P＜0.05）。结论华蟾素胶囊联合放疗对晚期胰腺癌疗效较佳，能够减轻胃肠道反应，且安全性良好，并能提高患者生活质量。

• Objective To investigate the efficacy of Huachansu combined with radiotherapy in patients with advanced pancreatic cancer. Methods Eighty-two patients with advanced pancreatic cancer admitted to Xianning Central Hospital from January 2010 to June 2016 were randomly divided into observation group and control group, with 41 cases in each group. The patients in the control group were treated with radiotherapy; the patients in the observation group were treated with Huachansu on the basis of the control group，4 weeks was 1 course. The therapeutic effect, 2-year survival rate and mean survival time were observed after 4 courses of treatment; the toxic reactions in the two groups were counted, including gastrointestinal reactions (nausea, vomiting), liver and kidney function damage and myelosuppression; the quality of life of the patients before and after treatment was evaluated according to the Chinese version of the quality of life scale for cancer patients. Results The total effective rate of observation group was significantly higher than that of control group ［48.8%(20/41) vs 26.8%(11/41)］; the 2-year survival rate was significantly higher than that of control group ［26.8%(11/41) vs 9.8%(4/41)］; the average survival time was longer than that of control group ［(10.2±2.2)months vs (8.1±1.7)months］(all P＜0.05). During the treatment, the incidence of gastrointestinal reactions in observation group was significantly lower than that in control group［17.1%(7/41) vs 36.6%(15/41)， P＜0.05］. After treatment, the quality of life scores of observation group were statistically higher than those of control group (P＜0.05). ConclusionThe combination of Huachansu and radiotherapy is effective in the treatment of advanced pancreatic cancer by reducing the gastrointestinal reaction and improving the quality of life.