2020 年第 8 期 第 15 卷

老年原发性高血压患者血清β2微球蛋白和踝臂指数的改变及其与血压变异性的关系

Study of serum β2-microglobulin, ankle-brachial index and blood pressure variability in elderly patients with essential hypertension

作者：崔秀卿1王志刚2王素玉1张玉凤1刘树理1邢金梅1朱宏利1

英文作者：Cui Xiuqing1  Wang Zhigang2 Wang Suyu1 Zhang Yufeng1  Liu Shuli1 Xing Jinmei1 Zhu Hongli1 

单位：1河北省保定市第二医院老年病科071000；2河北省保定恒兴中西医结合医院肿瘤内科071000 

英文单位：1Department of Geriatrics Baoding Second Hospital Hebei Province Baoding 071000 China; 2Department of Oncology Baoding Hengxing Integrated Chinese and Western Medicine Hospital Hebei Province Baoding 071000 China 

关键词：原发性高血压；β2微球蛋白；踝臂指数；血压变异性

英文关键词：Essentialhypertension;β2-microglobulin;Ankle-brachialindex;Bloodpressurevariability

• 摘要：

• 目的 探讨老年原发性高血压患者血清β2微球蛋白(β2-MG)和踝臂指数的改变及其与血压变异性（BPV）的关系。方法 选择2016年7月至2017年6月河北省保定市第二医院收治的147例老年原发性高血压患者为观察组，同期在本院健康体检者50例为对照组，检测并比较2组血清β2-MG水平及踝臂指数，检测并比较2组血压参数［24 h平均舒张压(24 h DBP)、24 h平均收缩压(24 h SBP)、24 h舒张压变异率(24 h DBPV)、24 h收缩压变异率(24 h SBPV)］，采用Pearson相关分析法分析原发性高血压患者β2-MG、踝臂指数与24 h DBP、24 h SBP、24 h DBPV、24 h SBPV的相关性，采用多元线性回归方法 分析原发性高血压患者24 h DBPV、24 h SBPV的影响因素。结果 观察组血清β2-MG水平明显高于对照组，踝臂指数明显低于对照组［（4.08±0.54）mg/L比（1.59±0.11）mg/L、（0.95±0.28）比（1.16±0.09）］，差异均有统计学意义（均P＜0.01）。观察组24 h DBP、24 h SBP、24 h DBPV、24 h SBPV明显大于对照组，差异均有统计学意义（均P＜0.01）。原发性高血压患者血清β2-MG水平与24 h DBP、24 h SBP、24 h DBPV、24 h SBPV均呈正相关（均P＜0.01）；踝臂指数与24 h DBP、24 h SBP、24 h DBPV、24 h SBPV均呈负相关（均P＜0.01）。β2-MG、踝臂指数是原发性高血压患者24 h DBPV、24 h SBPV的影响因素（非标准化回归系数分别为1.533、-0.188，1.820、-8.139，均P＜0.01）。结论 老年原发性高血压患者血清β2-MG水平呈升高趋势，踝臂指数呈下降趋势，二者均与BPV相关，BPV随血清β2-MG水平升高、踝臂指数下降而增高。

• Objective To investigate the changes of serum β2-microglobulin(β2-MG) and ankle-brachial index(ABI) in elderly patients with essential hypertension and therelation with blood pressure variability(BPV). Methods From July 2016 to June 2017, 147 elderly patients with essential hypertension(observation group) and 50 health people(control group) were enrolled at Baoding Second Hospital, Hebei Province. Serum β2-MG, ABI and blood pressure parameters［24 h mean diastolic blood pressure(24 h DBP), 24 h mean systolic blood pressure(24 h SBP), 24 h diastolic blood pressure variability(24 h DBPV), 24 h systolic blood pressure variability(24 h SBPV)］ were detected. Pearson correlation test was used to determine the correlation among β2-MG, ABI, 24 h DBP, 24 h SBP, 24 h DBPV and 24 h SBPV. Multivariate linear regression was used to analyze the influence factors of 24 h DBPV and 24 h SBPV. Results Serum β2-MG level in observation group was significantly higher and ABI was lower than those in control group［（4.08±0.54）mg/L vs （1.59±0.11）mg/L, （0.95±0.28） vs （1.16±0.09）］(both P<0.01). Values of 24 h DBP, 24 h SBP, 24 h DBPV and 24 h SBPV in observation group were significantly higher than those in control group(all P<0.01). Serum β2-MG level in hypertension patients was positively correlated with 24 h DBP, 24 h SBP, 24 h DBPV and 24 h SBPV(all P<0.05); ABI was negatively correlated with 24 h DBP, 24 h SBP, 24 h DBPV and 24 h SBPV(all P<0.01). Serum β2-MG level and ABI were influence factors of 24 h DBPV and 24 h SBPV(non-standardized regression coefficients: 1.533, -0.188, 1.820, -8.139; all P<0.01). Conclusions Elderly patients with essential hypertension show high serum β2-MG level and low ABI. BPV increase with serum β2-MG level and it is negatively related to the change of ABI.