2020 年第 8 期 第 15 卷

氧化三甲胺与心血管疾病关系的研究进展

Research progress of trimethylamine oxide and cardiovascular diseases 

作者：谢轲刘育 

英文作者：Xie Ke Liu Yu

单位：武汉大学人民医院心内科武汉大学心血管病研究所心血管病湖北省重点实验室430060

英文单位：Department of Cardiology Renmin Hospital of Wuhan University Cardiovascular Research Institute of Wuhan University， Hubei Key Laboratory of Cardiology Wuhan 430060 China 

关键词：心血管疾病；氧化三甲胺；肠道微生物学

英文关键词：Cardiovasculardiseases;TrimethylamineN-Oxide；Intestinalmicrobiology

• 摘要：

• 近年来肠道微生物与心血管疾病的相关性受到广泛关注，氧化三甲胺（TMAO）作为一种与肠道微生物相关的磷脂类代谢产物，与人们日常饮食息息相关。血浆TMAO浓度升高可能是心血管疾病风险增加的新标志。TMAO对包括心力衰竭、心律失常、高血压和冠状动脉粥样硬化性心脏病等心血管疾病的发生发展起重要作用。本文就TMAO与心血管疾病关系的研究进展进行综述。

• In recent years, the correlation between intestinal microbiota and cardiovascular disease has been widely analyzed; trimethylamine oxide (TMAO) is a phospholipid metabolite associated with gut microbiota, is closely related to daily diet. Elevated plasma TMAO may be a new sign of increased risk of cardiovascular disease.TMAO plays an important role in the development of cardiovascular diseases including heart failure, arrhythmias, hypertension and coronary atherosclerotic heart disease. This article reviewed the relationship between TMAO and cardiovascular disease.