2020 年第 11 期 第 15 卷

地尔硫卓对不稳定型心绞痛患者血清氧化应激指标及可溶性CD36水平的影响

Effect of diltiazem on serum oxidative stress index and soluble CD36 level in patients with unstable angina pectoris

作者：聂永军1李涛2陈宗伟3

英文作者：Nie Yongjun1 Li Tao2 Chen Zongwei3

单位：1浙江省医学科学院杭州医学院心内科310013；2浙江省医学科学院杭州医学院检验科310013；3大连大学附属中山医院循环二科116000

英文单位：1Department of Cardiology Zhejiang Academy of Medical Sciences Hangzhou Medical College Hangzhou 310013 China; 2Department of Clinical Laboratory Zhejiang Academy of Medical Sciences Hangzhou Medical College Hangzhou 310013 China; 3the Second Department of Circulatory Medicine the Affiliated Zhongshan Hospital of Dalian University Dalian 116000 China

关键词：不稳定型心绞痛；尼可地尔；地尔硫卓；氧化应激；可溶性CD36

英文关键词：Unstableanginapectoris;Nicorandil;Diltiazem;Oxidativestress;SolubleCD36

• 摘要：

• 目的 分析地尔硫卓对不稳定型心绞痛患者血清氧化应激指标及可溶性CD36水平的影响。方法 选取2015年12月至2017年10月在杭州医学院诊治的不稳定型心绞痛患者150例为研究对象。采用随机数字表法分为对照组（80例）和观察组（70例）。2组患者均给予不稳定型心绞痛的常规治疗，对照组患者在常规治疗的基础上给予尼可地尔治疗，观察组患者在对照组基础上给予地尔硫卓治疗，2组均治疗4周。比较2组患者的临床疗效及治疗前后血清氧化应激指标及可溶性CD36水平的变化。结果 观察组总有效率高于对照组［92.9%（65/70）比75.0%（60/80）］，差异有统计学意义（P<0.05）。治疗后观察组心绞痛发作频次及持续时间少于/短于对照组，差异均有统计学意义（均P<0.05）。治疗后2组还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NOX）2、NOX4、可溶性CD36、C反应蛋白水平较治疗前降低，且观察组低于对照组［（0.33±0.08）比（0.39±0.09）、（0.37±0.08）比（0.50±0.17）、（0.35±0.09）比（0.41±0.11）、（0.39±0.09）比（0.45±0.13）］，差异均有统计学意义（均P<0.05）。结论 地尔硫卓能有效治疗不稳定型心绞痛，可能与其影响患者血清中氧化应激指标及可溶性CD36水平有关。

• Objective To analyze the effect of diltiazem on serum oxidative stress index and soluble CD36 level in patients with unstable angina pectoris. Methods Totally 150 patients with unstable angina pectoris treated in Hangzhou Medical College from December 2015 to October 2017 were selected. They were randomly divided into control group(80 cases) and observation group(70 cases). Both groups were given routine treatment of unstable angina pectoris. The patients in control group were treated with nicorandil on the basis of routine treatment; the patients in observation group were treated with diltiazem on the basis of control group; both groups were treated for 4 weeks. The clinical effects of the two groups and the changes of serum oxidative stress and soluble CD36 levels were compared between the two groups before and after treatment. Results The total effective rate in observation group was significantly higher than that in control group［92.9%（65/70） vs 75.0%（60/80）］(P<0.05). After treatment, the frequency and duration of angina attack in observation group were less /shorter than those in control group; the differences were statistically significant(all P<0.05). After treatment, the levels of nicotinamide adenine dinucleotide phosphate oxidase (NOX) 2, NOX4, soluble CD36 and C-reactive protein in the two groups were lower than those before treatment, and those were lower in observation group than control group［（0.33±0.08） vs （0.39±0.09）, （0.37±0.08） vs （0.50±0.17）, （0.35±0.09） vs （0.41±0.11）, （0.39±0.09） vs （0.45±0.13）］; the differences were statistically significant(all P<0.05). ConclusionDiltiazem can effectively treat unstable angina pectoris, which may be related to the influence of oxidative stress index and soluble CD36 level in serum.