设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 

主管单位:中华人民共和国   

国家卫生健康委员会

主办单位:中国医师协会
总编辑:
杨秋

编辑部主任:吴翔宇

邮发代号:80-528
定价:28.00元
全年:336.00元
Email:zgyy8888@163.com
电话(传真):010-64428528;
010-64456116(总编室)

                  

过刊目录

2020 年第 11 期 第 15 卷

血清胱抑素C与25-羟维生素D及同型半胱氨酸在糖尿病肾病患者中的临床应用价值

Clinical application value of serum cystain C, 25-hydroxy vitamin D and homocysteine in diabetic nephropathy patients

作者:王莹吴东红程瑶梁桂敏马晶

英文作者:Wang Ying Wu Donghong Cheng Yao Liang Guimin Ma Jing

单位:哈尔滨市第一医院内分泌科一病房150010

英文单位:The First Ward Department of Endocrinology the First Hospital of Harbin Harbin 150010 China

关键词:2型糖尿病;糖尿病肾病;胱抑素C;25-羟维生素D;同型半胱氨酸

英文关键词:Type2diabetesmellitus;Diabeticnephropathy;CystainC;25-hydroxyvitaminD;Homocysteine

  • 摘要:
  • 目的 分析血清胱抑素C25-羟维生素D25-(OH)D]、同型半胱氨酸(Hcy)在糖尿病肾病(DN)患者中的临床应用价值。方法 选取20187月至20201月于哈尔滨市第一医院就诊的2型糖尿病并发DN患者90例作为观察组,根据尿白蛋白排泄率水平分为正常蛋白尿组(30例)、早期肾病组(32例)、临床肾病组(28例)3个亚组,另外选取同期在本院健康体检者30例作为对照组。比较各组血清胱抑素C25-(OH)DHcy水平。结果 正常蛋白尿组、早期肾病组和临床肾病组血清胱抑素CHcy水平均高于对照组[(0.69±0.28)、(0.92±0.31)、(1.37±0.36mg/L比(0.43±0.25mg/L,(10.7±3.2)、(13.7±3.8)、(17.0±4.3)μmol/L比(9.1±2.1)μmol/L],25-OHD水平均低于对照组[(27.5±2.6)、(22.5±4.8)、(20.6±3.4)μg/L比(35.7±3.6)μg/L],差异均有统计学意义(均P0.05)。临床肾病组血清胱抑素CHcy水平均高于早期肾病组和正常蛋白尿组,25-OHD水平低于早期肾病组和正常蛋白尿组;早期肾病组胱抑素CHcy水平均高于正常蛋白尿组,25-OHD水平低于正常蛋白尿组,差异均有统计学意义(均P0.05)。结论 血清胱抑素C25-OHDHcy水平与DN的发病和进展密切相关,监测三者水平有利于及时采取措施阻止或延缓DN发生或发展。

  • Objective To analyze the clinical application value of serum cystain C, 25-hydroxy vitamin D25-(OH)D and homocysteine (Hcy) in diabetic nephropathy(DN) patients. Methods From July 2018 to January 2020  90 patients in type 2 diabetes mellitus complicated with DN admitted to the First Hospital of Harbin were selected as the observation group. According to the urinary albumin excretion rate, they were divided into normal proteinuria group(30 cases), early nephropathy group(32 cases) and clinical nephropathy group(28 cases). In addition, 30 healthy people in our hospital during the same period were selected as the control group. The levels of cystatin C, 25-(OH)D and Hcy were compared among the four groups. Results The levels of cystatin C and Hcy in normal proteinuria group, early nephropathy group and clinical nephropathy group were higher and 25-(OH)D level was lower than those in control group[(0.69±0.28, 0.92±0.31, 1.37±0.36mg/L vs 0.43±0.25mg/L; 10.7±3.2, 13.7±3.8, 17.0±4.3)μmol/L vs 9.1±2.1)μmol/L;(27.5±2.6, 22.5±4.8, 20.6±3.4)μg/L vs 35.7±3.6)μg/L, the differences were statistically significant(all P<0.05). The levels of cystatin C and Hcy in clinical nephropathy group were higher and 25-(OH)D level was lower than those in early nephropathy group and normal proteinuria group, and the levels of cystatin C and Hcy in early nephropathy group were higher and 25-(OH)D level was lower than those in normal proteinuria group, and the differences were statistically significant(all P<0.05). Conclusions The serum levels of cystain C, 25-(OH)D and Hcy are closely related to the occurrence and progression of DN. Monitoring the three indexes levels is conducive to take timely measures to prevent or delay DN occurrence or development.

copyright 《中国医药》杂志编辑部
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层
电话:010-64456116 传真:010-64428528 邮编:100029 Email: zgyy8888@163.com
网址:www.chinamedicinej.com 京ICP备2020043099号-3

当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com。







安卓


苹果

关闭