2020 年第 11 期 第 15 卷

肠道菌群代谢产物短链脂肪酸调节血压的可能机制及作为靶点防治高血压的研究进展

Research progress on mechanisms of blood pressure regulation, prevention and treatment of hypertension by gut microbiota metabolite short-chain fatty acids

作者：李棣文刘育

英文作者：Li Diwen Liu Yu

单位：武汉大学人民医院心血管内科武汉大学心血管病研究所心血管病湖北省重点实验室430060

英文单位：Department of Cardiovascular Medicine Renmin Hospital of Wuhan University Cardiovascular Research Institute of Wuhan University Hubei Key Laboratory of Cardiology Wuhan 430060 China

关键词：高血压；短链脂肪酸；肠道菌群

英文关键词：Hypertension；Short-chainfattyacids；Gutmicrobiota

• 摘要：

• 高血压作为心血管疾病的重要危险因素，多种机制可参与其发生发展。研究提示肠道菌群与高血压存在密切联系，其中肠道菌群的代谢产物——短链脂肪酸可以通过多种途径参与高血压的发生发展，如特定受体、免疫系统以及自主神经系统等。本文对短链脂肪酸调控高血压的可能机制以及短链脂肪酸作为靶点防治高血压的前景进行综述。

• Hypertension is an important risk factor for cardiovascular diseases. Studies suggest that gut microbiota is closely related to hypertension. Increasing evidence shows that short-chain fatty acids (SCFAs) which are metabolites of the gut microbiota, can participate in the development of hypertension through multiple pathways, such as specific receptors, the immune system and the autonomic nervous system. This article reviewed the possible mechanisms of SCFAs regulating hypertension and the prospects of SCFAs.