2021 年第 1 期 第 16 卷

帕金森病患者伴发焦虑抑郁的影响因素分析

Related factors of anxiety and depression in patients with Parkinson′s disease

作者：柴滨马惠姿冯涛

英文作者：Chai Bin Ma Huizi Feng Tao

单位：首都医科大学附属北京天坛医院神经病学中心运动障碍性疾病科100070

英文单位：Department of Neurodegenerative Disease Center of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100070 China

关键词：帕金森病；焦虑；抑郁

英文关键词：Parkinson′sdisease;Anxiety;Depression

• 摘要：

• 目的 分析帕金森病伴发焦虑、抑郁的影响因素。方法 选取2016年1—10月于首都医科大学附属北京天坛医院住院确诊的135例帕金森病患者。通过进行统一帕金森病评定量表（UPDRS），改良的Hoehn-Yahr分期，汉密尔顿焦虑量表，汉密尔顿抑郁量表的评测，统计分析本组患者焦虑、抑郁的发生率，同时分析患者性别、年龄、文化程度、起病类型、病程、家族史等对焦虑、抑郁的影响。结果 本组帕金森病患者中，焦虑发病率为53.3%（72/135），抑郁发病率为65.2%（88/135）。单因素分析发现无焦虑与有焦虑患者在病程、UPDRS评分、躯体因子得分、精神因子得分和二项总分方面差异均有统计学意义（均P<0.01）；无抑郁与有抑郁患者在病程、UPDRS评分、各因子得分和七项因子总分方面差异均有统计学意义（均P<0.01）。Logistic回归分析结果显示病程是帕金森病患者伴发焦虑和抑郁的影响因素，差异均有统计学意义（焦虑比值比=3.432，95%置信区间：1.539～7.657，P=0.003；抑郁比值比=2.237，95%置信区间：1.017～4.922，P=0.045）。结论 焦虑、抑郁均是帕金森病最常见的非运动症状，发生率高，帕金森病患者的病程、运动症状严重程度与焦虑、抑郁明显相关，而病程相关性更加密切。

• Objective To analyze the related factors of anxiety and depression in patients with Parkinson′s disease(PD). Methods The clinical data of 135 patients with PD admitted to Beijing Tiantan Hospital, Capital Medical University from January to October 2016 were collected. The incidence of anxiety and depression was evaluated by the Unified Parkinson Disease Rating Scale(UPDRS), the modified version of the Hoehn-Yahr Scale, the Hamilton Anxiety Scale, and the Hamilton Depression Scale. Influences of patients′ gender, age, education level, type of onset, course of disease and family history on anxiety and depression were analyzed. Results The incidence of anxiety in patients with PD was 53.3%(72/135), and depression was 65.2%(88/135). Univariate analysis showed that there were significant differences in duration of disease, UPDRS score, somatic factor score, mental factor score and total score of two items between patients without anxiety and those with anxiety(all P<0.01). There were significant differences in duration of disease, UPDRS score, scores of each factor and total score of seven factors between patients without depression and those with depression(all P<0.01). Logistic regression analysis showed that duration of disease was the influencing factor of anxiety and depression in patients with PD, and the differences were statistically significant(odds ratio of anxiety=3.432, 95% confidence interval: 1.539-7.657, P=0.003; odds ratio of depression=2.237, 95% confidence interval: 1.017-4.922, P=0.045). Conclusions  Anxiety and depression are the most common non-motor symptoms of PD. Both symptoms have a high incidence and significantly correlated to duration of PD and the severeness of motor symptoms and duration of PD is more closely correlated.