2021 年第 3 期 第 16 卷

肺结核患者血清γ干扰素诱导蛋白10和细胞因子信号转导抑制物1水平变化及临床意义

Changes and clinical significances of serum interferon-gamma-inducible protein-10 and suppressor of cytokine singaling 1 levels in patients with pulmonary tuberculosis

作者：吴向华高军田琦仇艳君

英文作者：Wu Xianghua Gao Jun Tian Qi Qiu Yanjun

单位：黑龙江省传染病防治院黑龙江省第四医院结核内科，哈尔滨150500

英文单位：Department of Tuberculosis Medicine Infectious Disease Hospital of Heilongjiang Province the Fourth Hospital of Heilongjiang Province Harbin 150500 China

关键词：肺结核；γ干扰素诱导蛋白10；细胞因子信号转导抑制物1；相关性；诊断价值

英文关键词：Pulmonarytuberculosis;Interferon-gamma-inducibleprotein-10;Suppressorofcytokinesingaling1;Correlation;Diagnosticvalue

• 摘要：

• 目的 探讨肺结核患者血清γ干扰素诱导蛋白10(IP-10)、细胞因子信号转导抑制物1(SOCS1)水平变化及临床意义。方法 选取黑龙江省第四医院2018年10月至2019年9月收治的90例肺结核患者，根据不同类型分为活动性结核组（34例）、潜伏性结核感染组（31例）、治疗完成组（25例），另选取同期体检健康者42例为对照组。比较4组血清IP-10、SOCS1水平，Pearson相关性分析方法分析肺结核患者血清IP-10水平与SOCS1水平的相关性，绘制受试者工作特征（ROC）曲线分析血清IP-10、SOCS1水平对肺结核的诊断价值。结果 对照组、治疗完成组、潜伏性结核感染组、活动性结核组血清IP-10水平逐渐升高［（75±8）、（82±7）、（88±10）、（93±11）ng/L］，SOCS1水平逐渐降低［（215±28）、（200±19）、（180±26）、（168±19）μg/L］，两两比较差异均有统计学意义(均P＜0.05)。Pearson相关性分析显示，肺结核患者血清IP-10水平与SOCS1水平呈负相关(r=-0.620，P＜0.001)。ROC曲线显示，血清IP-10+SOCS1［曲线下面积（AUC）=0.906，95%置信区间：0.858～0.955］诊断肺结核的敏感度、特异度、准确度高于IP-10(AUC=0.833，95%置信区间：0.764～0.903)、SOCS1(AUC=0.835，95%置信区间：0.760～0.911)单独诊断(Z=3.135、2.641，P=0.002、0.008)。结论 肺结核患者血清IP-10水平明显升高，SOCS1水平明显降低，二者呈负相关，且均与肺结核进展密切相关，联合检测能提升对肺结核的诊断价值。

• Objective To investigate the changes and clinical significances of serum interferon-gamma-inducible protein-10 (IP-10) and suppressor of cytokine singaling 1 (SOCS1) levels in patients with pulmonary tuberculosis (TB). Methods From October 2018 to September 2019, 90 TB patients admitted to the Fourth Hospital of Heilongjiang Province were selected. The patients were divided into active tuberculosis group(34 cases), latent tuberculosis infection group(31 cases) and treatment completion group(25 cases) according to different types. In addition, 42 healthy people underwent physical examination were selected as the control group. The serum IP-10 and SOCS1 levels were compared among the four groups. Pearson correlation analysis was used to analyze the correlation between serum IP-10 and SOCS1 levels in TB patients. Receiver operating characteristic (ROC) curve was used to analyze diagnostic values of serum IP-10 and SOCS1 levels in TB. Results The serum IP-10 levels of the control group, the treatment completion group, the latent tuberculosis infection group, and the active tuberculosis group increased gradually［（75±8）,（82±7）,（88±10）,（93±11）ng/L］, and the SOCS1 levels   reduced gradually［（215±28）,（200±19）,（180±26）,（168±19）μg/L］. The differences between pairwise comparisons  were statistically significant(all P＜0.05). Pearson correlation analysis showed that serum IP-10 level was negatively correlated with SOCS1 level in TB patients (r=-0.620, P＜0.001). ROC curve showed that the sensitivity, specificity and accuracy of serum IP-10+SOCS1 ［area under the curve(AUC)=0.906, 95% confidence interval(CI):0.858-0.955］ in the diagnosis of TB were higher than those of IP-10 (AUC=0.833, 95%CI: 0.764-0.903) and SOCS1 (AUC=0.835, 95%CI: 0.760-0.911)(Z=3.135, 2.641; P=0.002, 0.008). Conclusions The level of serum IP-10 in patients with TB is significantly increased, and the level of SOCS1 is significantly decreased. IP-10 and SOCS1 are negatively correlated and closely related to the progress of TB. Combined detection can enhance the diagnostic value of tuberculosis.