设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 

主管单位:中华人民共和国   

国家卫生健康委员会

主办单位:中国医师协会
总编兼编辑部主任:
杨秋

邮发代号:80-528
定价:20.00元
全年:240.00元
Email:zgyy8888@163.com
电话(传真):010-64428528;
010-64456116(总编室)

                  

过刊目录

2021 年第 4 期 第 16 卷

血清黏着斑激酶及左心室质量指数与老年急性ST段抬高型心肌梗死患者经皮冠状动脉介入术后左心室重构的关系

Relationship between serum focal adhesion kinase, left ventricular mass index and left ventricular remodeling in elderly patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention

作者:张小坤刘英华王玉霞刘亚宁谢明高晓丽

英文作者:Zhang Xiaokun Liu Yinghua Wang Yuxia Liu Yaning Xie Ming Gao Xiaoli

单位:华北石油管理局总医院心内一科,河北省任丘市062550

英文单位:The First Department of Cardiology Huabei Petroleum Administration Bureau General Hospital Hebei province Renqiu 062550 China

关键词:急性ST段抬高型心肌梗死;经皮冠状动脉介入;血清黏着斑激酶;左心室质量指数;左心室重构

英文关键词:AcuteST-segmentelevationmyocardialinfarction;Percutaneouscoronaryintervention;Serumfocaladhesionkinase;Leftventricularmassindex;Leftventricularremodeling

  • 摘要:
  • 目的 探讨血清黏着斑激酶(FAK)水平及左心室质量指数(LVMI)与老年急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后左心室重构的关系。方法 选取20171月至20181月华北石油管理局总医院收治的102例老年急性STEMIPCI治疗患者作为观察组,选取同期于本院行健康体格检查的50例志愿者作为对照组。根据观察组患者是否发生左心室重构,分为重构组(36例)和非重构组(66例)。观察组于入院48 h内和PCI术后6个月、对照组于入组时行血清FAK水平、心脏超声检查,比较观察组与对照组以及重构组与非重构组检查结果的差异。结果 观察组入院48 h内血清FAK水平、LVMI均高于对照组[(31±5)μg/L比(25±4)μg/L、(90±13g/m2比(80±13g/m2],左心室射血分数(LVEF)低于对照组[(55±10% 65±13%],差异均有统计学意义(均P<0.001)。PCI术后6个月,重构组血清FAK水平、左心室舒张末期容积(LVEDV)、LVMI均高于本组入院48 h内,且均高于非重构组[(47±6)μg/L比(33±5)μg/L、(117±16ml比(102±14ml、(96±15g/m2比(90±14g/m2],LVEF低于入院48 h内,且低于非重构组[(49±8%比(55±9%],差异均有统计学意义(均P<0.05)。Pearson相关性分析显示,重构组血清FAK水平及LVMILVEDV均呈正相关、与LVEF均呈负相关(r=0.5940.543-0.369-0.411,均P<0.001)。结论 老年急性STEMI PCI术后左心室重构患者血清FAK水平、LVMILVEDV呈正相关,与LVEF均呈负相关,FAKLVMI水平升高可能提示左心室结构改变。

  • Objective To investigate the relationship between serum focal adhesion kinase (FAK) level, left ventricular mass index (LVMI) and left ventricular remodeling in elderly patients with acute ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). Methods Totally 102 elderly acute STEMI patients who underwent PCI in Huabei Petroleum Administration Bureau General Hospital from January 2017 to January 2018 were enrolled as observation group. Fifty healthy volunteers who underwent physical examination in the hospital at the same period were enrolled as control group. According to occurrence of left ventricular remodeling in patients of observation group, they were divided into remodeling group(36 cases) and non-remodeling group (66 cases). Serum FAK levels and echocardiogram were detected within 48 h of admission and 6 months after PCI in observation group and at enrollment in control group, and were compared between observation group and control group, remodeling group and non-remodeling group. Results The serum FAK level and LVMI of observation group within 48 h after admission were higher than those of control group[(31±5)μg/L vs 25±4)μg/L, 90±13g/m2 vs 80±13g/m2, and left ventricular ejection fraction (LVEF) of observation group was lower than that of control group[(55±10% vs 65±13%(all P<0.001). Six months after PCI, serum FAK level, left ventricular end diastolic volume (LVEDV) and LVMI of remodeling group were higher than those within 48 h after admission and those of non-remodeling group[(47±6)μg/L vs 33±5)μg/L,117±16ml vs 102±14ml,96±15g/m2 vs 90±14g/m2; LVEF of remodeling group was lower than that within 48 h after admission and that of non-remodeling group[(49±8% vs 55±9% (all P<0.05). Pearson correlation analysis showed that serum FAK level and LVMI in remodeling group were positively correlated with LVEDV, and negatively correlated with LVEF (r=0.594, 0.543, -0.369, -0.411, all P<0.001). Conclusions  Serum FAK level and LVMI are positively correlated with LVEDV and negatively correlated with LVEF in acute STEMI elderly patients with left ventricular remodeling after PCI. The increase of serum FAK level and LVMI may indicate the structural change of left ventricle.

copyright 《中国医药》杂志编辑部
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层
电话:010-64456116 传真:010-64428528 邮编:100029 Email: zgyy8888@163.com
网址:www.chinamedicinej.com 京ICP备2020043099号-3
本系统由北京博思汇文数字科技有限公司设计开发 技术服务电话:010-60213898
当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com。







安卓


苹果

关闭