2021 年第 5 期 第 16 卷

心外膜脂肪组织及其与冠状动脉粥样硬化关系的研究进展

Research progress of epicardial adipose tissue and its relationship with coronary atherosclerosis

作者：刘晋星刘妍赵迎新

英文作者：Liu Jinxing Liu Yan Zhao Yingxin

单位：首都医科大学附属北京安贞医院心内科北京市心肺血管疾病研究所100029

英文单位：Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China

关键词：心外膜脂肪组织；冠状动脉粥样硬化

英文关键词：Epicardialadiposetissue;Coronaryatherosclerosis

• 摘要：

• 心外膜脂肪组织是指位于心肌表面与脏层心包之间的脂肪组织，包绕着冠状血管的主要分支，与心肌及血管并无明显的解剖界限。心外膜脂肪组织的量可由超声、CT、磁共振成像等进行测量。研究发现心外膜脂肪与冠心病（冠状动脉粥样硬化性心脏病）密切相关。关于心外膜脂肪转录组的基因调控机制的研究为心血管疾病的治疗和预防开辟了新的途径，心外膜脂肪有望成为未来心血管病的治疗靶点。

• Epicardial adipose tissue (EAT) refers to the adipose tissue located between the surface of the myocardium and the visceral pericardium, which surrounds the main branches of the coronary vessels and has no obvious anatomical boundary with the myocardium and blood vessels. The amount of EAT can be measured by ultrasound, CT as well as magnetic resonance imaging. Studies find that EAT is closely related to coronary atheroscleroticheart disease. The researches on the gene regulation mechanism of EAT transcriptome open up a new way for the treatment and prevention of cardiovascular diseases and EAT is expected to become a therapeutic target for cardiovascular diseases.