2021 年第 7 期 第 16 卷

枸橼酸氯米芬联合小檗碱对多囊卵巢综合征患者卵巢形态及血流动力学的影响

Effects of clomifene citrate combined with berberine on ovarian morphology and hemodynamics in patients with polycystic ovary syndrome

作者：杨丹丹桑敏

英文作者：Yang Dandan Sang Min

单位：哈尔滨市第一医院门诊妇产科150010

英文单位：Outpatient of Obstetrics and Gynecology Harbin the First Hospital， Harbin 150010 China

关键词：多囊卵巢综合征；小檗碱；枸橼酸氯米芬

英文关键词：Polycysticovarysyndrome;Berberine;Clomifenecitrate

• 摘要：

• 目的 探讨枸橼酸氯米芬联合小檗碱对多囊卵巢综合征（PCOS）患者卵巢形态及血流动力学的影响。方法 选取2020年1—8月就诊于哈尔滨市第一医院的50例PCOS患者，根据随机数字表法分为对照组和观察组，各25例。2组患者均予枸橼酸氯米芬治疗，对照组在此基础上联合二甲双胍治疗、观察组在此基础上联合小檗碱治疗，2组均连续治疗3个月经周期。比较2组治疗前后卵巢形态及血流动力学指标。对患者进行3个月随访，记录2组规律月经比例及排卵比例。结果 治疗后，2组卵巢包膜厚度、卵巢体积、卵泡数量均低于治疗前，且观察组均低于对照组［（1.10±0.19）mm比（1.60±0.18）mm、（7.9±1.3）ml比（10.5±1.6）ml、（9.2±1.4）个比（12.7±1.5）个］，2组卵泡直径均大于治疗前，且观察组大于对照组［（9.1±1.2）mm比（7.0±1.2）mm］，差异均有统计学意义（均P＜0.05）。治疗后，2组卵巢动脉平均血流速度均高于治疗前，且观察组高于对照组；2组搏动指数、阻力指数均低于治疗前，且观察组均低于对照组，差异均有统计学意义（均P＜0.05）。随访期间观察组规律月经比例、排卵比例均高于对照组，差异均有统计学意义（均P＜0.05）。结论 枸橼酸氯米芬联合小檗碱可有效改善PCOS患者的卵巢形态及血流动力学，纠正月经及排卵异常。

• Objective To investigate the effects of clomifene citrate combined with berberine on ovarian morphology and hemodynamics in patients with polycystic ovary syndrome (PCOS). Methods From January to August 2020, 50 patients with PCOS admitted to Harbin the First Hospital were enrolled. They were randomly divided into the control group and the observation group, with 25 cases in each group. All patients were treated with clomifene citrate. The control group was treated with metformin on the basis of clomiphene, and the observation group was treated with berberine on the basis of clomifene citrate. Both groups were treated for 3 menstrual cycles. The ovarian morphology and hemodynamics indexes were compared between the two groups before and after treatment. The patients were followed-up for 3 months, and the proportions of regular menstruation and ovulation in the two groups were recorded. Results After treatment, the ovarian envelope depth, ovarian volume and follicle number in both groups were lower than those before treatment, and those in observation group were lower than those in control group［(1.10±0.19)mm vs (1.60±0.18)mm, (7.9±1.3)ml vs (10.5±1.6)ml, (9.2±1.4) vs (12.7±1.5)］(all P<0.05). The follicle diameter in both groups after treatment were larger than those before treatment, and that in observation group was larger than that in control group［(9.1±1.2)mm vs (7.0±1.2)mm］(all P<0.05). After treatment, the ovarian artery average blood flow velocity in both groups were higher than those before treatment, and that in observation group was higher than that in control group(all P<0.05); the pulse index and resistance index in both groups were lower than those before treatment, and those in observation group were lower than those in control group (all P<0.05). During followed-up period, the proportions of regular menstruation and ovulation in observation group were higher than those in control group, and the differences were statistically significant (both P<0.05). Conclusion Clomifene citrate combined with berberine can effectively improve the ovarian morphology and hemodynamics of patients with PCOS, and correct menstruation and ovulation disorder.