2021 年第 8 期 第 16 卷

脂毒性对胰岛素抵抗及胰岛β细胞功能的影响研究进展

Research progress on effects of lipotoxicity on insulin resistance and pancreatic β cell function

作者：郝一聪1李强2于萍1

英文作者：Hao Yicong1 Li Qiang2 Yu Ping1

单位：1广东省深圳市萨米医疗中心内分泌科518000；2深圳大学总医院内分泌科518055

英文单位：1Department of Endocrinology Shenzhen Samii Medical Center Guangdong Province Shenzhen 518000 China; 2Department of Endocrinology Shenzhen University General Hospital Shenzhen 518055 China

关键词：2型糖尿病；脂毒性；游离脂肪酸；胰岛素抵抗；胰岛β细胞功能

英文关键词：Type2diabetesmellitus;Lipotoxicity;Freefattyacid;Insulinresistance;Pancreaticβcellfunction

• 摘要：

• 2型糖尿病（T2DM）患者常合并脂质水平和代谢异常。糖尿病会使脂解作用加强，脂肪酸在体内超过脂肪组织储存阈值，会沉积在周围组织并产生破坏性影响，称为脂毒性。脂毒性造成的骨骼肌胰岛素抵抗和胰岛β细胞损伤成为T2DM疾病进展的重要环节。因此，本文就关于脂毒性对T2DM疾病进程中胰岛素抵抗和胰岛β细胞功能受损影响的基础及临床研究进展进行综述。

• Patients with type 2 diabetes mellitus (T2DM) often have abnormal lipid levels and lipid metabolise. Diabetes mellitus will strengthen lipolysis. The large amounts of fatty acids in the body exceeding the storage threshold of adipose tissue will be deposited in surrounding tissues and have a destructive effect, which is called lipotoxicity. Skeletal muscle insulin resistance and pancreatic β cell damage caused by lipotoxicity become an important link in the progression of T2DM. Therefore, this article reviews the basic and clinical research progress on the impact of lipotoxicity on insulin resistance and impaired pancreatic β cell function in the progression of T2DM.