2022 年第 2 期 第 17 卷

人类宿主易感基因多态性与结核病和耐药结核病的相关性研究进展

Research progress on the association between human host susceptibility gene polymorphism and tuberculosis and drug-resistant tuberculosis

作者：魏清雯1王慧1夏茸1万毅新1张文丽2

英文作者：Wei Qingwen1 Wang Hui1 Xia Rong1 Wan Yixin1 Zhang Wenli2

单位：1兰州大学第二临床医学院，兰州730030；2甘肃省兰州市肺科医院二病区，兰州730000

英文单位：1The Second Clinical Medical School Lanzhou University Lanzhou 730030 China; 2the Second Ward Pulmonology Hospital of Lanzou Gansu Province Lanzhou 730000 China

关键词：结核病；耐药结核病；基因多态性

英文关键词：Tuberculosis;Drug-resistanttuberculosis;Genepolymorphism

• 摘要：

• 结核病和耐药结核病对人类的危害较大，当前大部分研究聚焦于结核感染发病的免疫应答机制过程中的调控基因，部分研究从细胞因子基因入手。而在药物代谢机制方面的研究，仅有人类白细胞抗原、维生素D受体、多耐药基因1涉及了基因与耐药结核的关系。人类宿主易感基因由于不同种族、人群差异等造成研究结果差别较大。本文就目前已知的与结核病、耐药结核病相关的人类宿主易感基因进行综述，旨在为后续的结核易感基因研究提供参考。

• Tuberculosis and drug-resistant tuberculosis are harmful to human beings. At present, most studies focus on the regulatory genes in the immune response mechanism of tuberculosis infection, and some studies start with cytokine genes. In the study of drug metabolism mechanism, only the human leukocyte antigen, vitamin D receptor and multidrug resistance gene 1 are involved in the relationship between genes and drug-resistant tuberculosis. The research results of human host susceptibility genes change greatly due to the differences of races and population. This article reviews the known human host susceptibility genes related to tuberculosis and drug-resistant tuberculosis, hoping to provide a reference for the subsequent study of tuberculosis susceptibility genes.