2022 年第 2 期 第 17 卷

成纤维细胞生长因子2在纤维化疾病中表达的研究进展

Research progress of the expression of fibroblast growth factor-2 in fibrotic diseases

作者：彭霞夏悦杨艺娇谢佳妮刘虹麟倪晓容

英文作者：Peng Xia Xia Yue Yang Yijiao Xie Jiani Liu Honglin Ni Xiaorong

单位：上海中医药大学附属市中医医院妇科，上海200071

英文单位：Department of Gynaecology Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200071 China

关键词：成纤维细胞生长因子2；纤维化疾病；肺纤维化；肝纤维化；肾纤维化；心肌纤维化；皮肤纤维化

英文关键词：Fibroblastgrowthfactor-2;Fibroticdiseases;Pulmonaryfibrosis;Liverfibrosis;Renalfibrosis;Myocardialfibrosis;Skinfibrosis

• 摘要：

• 成纤维细胞生长因子2(FGF-2)是一种促进血管生成的因子,能够在多种细胞和组织中表达，并参与细胞迁移、细胞分化和各种发育过程。虽然FGF-2缺乏经典的分泌信号肽，但其可以通过结合高亲和力的跨膜FGF受体（FGFR）和辅助因子硫酸乙酰肝素蛋白多糖(HSPG)以FGF-2-HSPG-FGFR三元复合物的形式在细胞内发生磷酸化,并调节多种细胞的功能，参与正常伤口愈合和组织发育。近年来研究表明FGF-2对纤维化疾病的形成具有调节作用,在肺、肝、肾、心肌和皮肤纤维化中均存在FGF-2/FGFR信号通路的异常表达。本文对FGF-2在纤维化疾病中的研究进展进行综述,为FGF-2靶向治疗纤维化疾病提供参考。

• Fibroblast growth factor-2(FGF-2), a member of angiogenic cytokines, can be expressed in a variety of cells and tissues and is involved in cell migration, cell differentiation and various developmental processes. Although FGF-2 lacks classical secretory signal peptide, it can bind to high affinity transmembrane FGF receptor (FGFR) and heparan sulfate proteoglycan (HSPG) and be phosphorylated in the form of FGF-2-HSPG-FGFR ternary complex, regulates the function of various cells and participates in the pathogenesis of normal wound healing and tissue development. In recent years, studies have shown that FGF-2 plays a regulatory role in the formation of fibrotic diseases. Abnormal expression of FGF-2/FGFR signaling pathway exists in lung, liver, kidney, heart and skin fibrosis. In this paper, the research progress of FGF-2 in fibrotic diseases is reviewed to provide a reference for the future research of FGF-2 targeted treatment in fibrotic diseases. font:minor-fareast;mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin'>倪晓容