2022 年第 4 期 第 17 卷

CD8+ T细胞在大动脉炎发病机制中的作用研究进展

Research progress on the role of CD+8 T cell in the pathogenesis of Takayasu arteritis

作者：张子玉1杜娟2李涛涛2潘丽丽2

英文作者：Zhang Ziyu1 Du Juan2 Li Taotao2 Pan Lili2

单位：1首都医科大学第六临床医学院2018级临床医学专业，北京100069；2首都医科大学附属北京安贞医院风湿免疫科，北京100029

英文单位：1Undergraduate of Clinical Medicine Specialty Grade 2018 the Sixth Clinical Medical School Capital Medical University Beijing 100069 China; 2Department of Rheumatology and Immunology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

关键词：大动脉炎；CD8+ T细胞；血管炎；细胞因子 

英文关键词：Takayasuarteritis；CD+8Tcell；Vasculitis；Cytokines

• 摘要：

• 大动脉炎是一种慢性大血管炎，其病因尚未完全阐明，T细胞介导的免疫反应是大动脉炎目前公认的主要发病机制。目前已投入临床使用的多种治疗药物表现出了对大动脉炎疗效的局限性，阐明大动脉炎发病机制对寻找新的药物治疗靶点有重要意义。CD+8T细胞是大动脉炎病理位置的主要浸润细胞之一,在大动脉炎中活化显著增加，能够通过直接损伤血管壁细胞及分泌细胞因子的方式参与大动脉炎的发生与发展。本文就CD+8T细胞在大动脉炎发病机制中的作用进行综述。

• Takayasu arteritis (TAK) is a chronic large vessel vasculitis and its etiology has not been fully elucidated. T-cell-mediated immune response is currently recognized as the main pathogenesis of TAK. At present, a variety of therapeutic drugs that have been put into clinical use have shown limitations in the treatment of TAK. Elucidating its pathogenesis is of great significance to develop new therapeutic targets. CD+8T cell is one of the main infiltrating cells in the pathological location of TAK, which also show a significantly increasing activation in TAK. It can participate in the occurrence and development of TAK by directly damaging vascular wall cells and secretion of cytokines. This paper reviews the role of CD+8T cell in the pathogenesis of TAK.