2022 年第 5 期 第 17 卷

滋肾调脾敛汗方治疗阴虚火旺型围绝经期汗症的效果及对患者神经内分泌系统的影响

Effect of Zishen Tiaopi Lianhan prescription on perimenopausal hyperhidrosis of Yin-deficiency and fire hyperactivity type and its influence on neuroendocrine system

作者：闫华杨戈王淑丽

英文作者：Yan Hua Yang Ge Wang Shuli

单位：中国中医科学院广安门医院老年科，北京100053

英文单位：Department of Geriatrics Guang′anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China

关键词：围绝经期；汗症；阴虚火旺；滋肾调脾敛汗方

英文关键词：Perimenopausal;Hyperhidrosis;Yin-deficiencyandfirehyperactivity;ZishenTiaopiLianhanprescription

• 摘要：

• 目的 探讨滋肾调脾敛汗方治疗阴虚火旺型围绝经期汗症的效果及对患者神经内分泌系统的影响。方法 选取2017年6月至2019年10月中国中医科学院广安门医院收治的阴虚火旺型围绝经期汗症患者82例，采用随机数字表法分为观察组和对照组，各41例。对照组采用玉屏风颗粒治疗，观察组在对照组基础上加用滋肾调脾敛汗方治疗。比较2组治疗前后主症评分、次症评分及总评分，临床疗效，治疗前后神经内分泌系统指标，并比较2组治疗期间不良反应发生情况。结果治疗后，2组患者主症评分、次症评分、总评分均低于治疗前，且观察组均低于对照组［（2.2±0.4）分比（4.4±0.7）分、（1.7±0.5）分比（3.1±0.7）分、（3.8±0.7）分比（7.5±1.5）分］，差异均有统计学意义（均P＜0.05）。观察组总有效率高于对照组［97.6%(40/41)比82.9%(34/41)］，差异有统计学意义（P＜0.05）。治疗后2组血清5-羟色胺、雌二醇、孕酮水平均明显高于治疗前，且观察组高于对照组［（183±29）μg/L比（169±28）μg/L、（97±10）pmol/L比（92±9）pmol/L、（2.2±0.4）μg/L比（1.9±0.4）μg/L］（均P＜0.05），2组血清促卵泡生成素、促黄体生成素水平均明显低于治疗前，且观察组均低于对照组［（26±4）IU/L比（39±5）IU/L、（17±4）IU/L比（21±4）IU/L］（均P＜0.05）。2组治疗期间不良反应发生率比较差异无统计学意义（P=0.644）。结论  滋肾调脾敛汗方能有效缓解阴虚火旺型围绝经期汗症患者汗症症状，疗效显著，还可改善患者神经内分泌系统指标，且安全性较好。

• Objective  To investigate the effect of Zishen Tiaopi Lianhan prescription on perimenopausal hyperhidrosis of Yin-deficiency and fire hyperactivity type and its influence on neuroendocrine system. Methods From June 2017 to October 2019, 82 cases of perimenopausal hyperhidrosis of Yin-deficiency and fire hyperactivity type in Guang′anmen Hospital, China Academy of Chinese Medical Sciences were selected. They were randomly divided into observation group and control group, with 41 cases in each group. The control group was treated with Yupingfeng granule, while the observation group was treated with Zishen Tiaopi Lianhan prescription on the basis of the control group. The main symptom score, secondary symptom score and total score before and after treatment, clinical efficacy, neuroendocrine system indexes before and after treatment and adverse reactions during treatment were compared between the two groups. Results  After treatment, the main symptom score, secondary symptom score and total score of the two groups decreased, and those of the observation group were lower than those of the control group［（2.2±0.4） vs （4.4±0.7）, （1.7±0.5） vs （3.1±0.7）, （3.8±0.7） vs （7.5±1.5）］ (all P＜0.05). The total effective rate of the observation group was higher than that of the control group［97.6%(40/41) vs 82.9%(34/41)］(P＜0.05). After treatment, the levels of 5-hydroxytryptamine, estradiol and progesterone of the two groups increased, and those of the observation group were higher than those of the control group［（183±29）μg/L vs （169±28）μg/L, （97±10）pmol/L vs （92±9）pmol/L, （2.2±0.4）μg/L vs （1.9±0.4）μg/L］ (all P＜0.05). After treatment, the level ffollicle stimulating hormone and luteinizing hormone of the two groups decreased, and those of the observation group were lower than those of the control group［（26±4）IU/L vs （39±5）IU/L, （17±4）IU/L vs （21±4）IU/L］(all P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P=0.644). Conclusions Zishen Tiaopi Lianhan prescription can effectively relieve the symptoms of perimenopausal hyperhidrosis of Yin-deficiency and fire hyperactivity type, with significant curative effect. It can also improve the indexes of neuroendocrine system, with good safety.