设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 

主管单位:中华人民共和国   

国家卫生健康委员会

主办单位:中国医师协会
总编辑:
杨秋

编辑部主任:吴翔宇

邮发代号:80-528
定价:28.00元
全年:336.00元
Email:zgyy8888@163.com
电话(传真):010-64428528;
010-64456116(总编室)

                  

过刊目录

2022 年第 3 期 第 17 卷

低密度脂蛋白受体对三阴性乳腺癌患者预后的影响

Effect of low-density lipoprotein receptor on prognosis of patients with triple-negative breast cancer

作者:亓琳鞠瑛张培莉陈兰兰邹建文

英文作者:Qi Lin Ju Ying Zhang Peili Chen Lanlan Zou Jianwen

单位:山东第一医科大学附属省立医院临床检验医学部,济南250021

英文单位:Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 China

关键词:三阴性乳腺癌;低密度脂蛋白受体;淋巴结转移;无病生存期;总生存期

英文关键词:

  • 摘要:
  • 目的 探讨低密度脂蛋白受体(LDLR)对三阴性乳腺癌患者预后的影响。方法  回顾性分析山东第一医科大学附属省立医院20101月至201612月收治的107例三阴性乳腺癌患者和136例乳腺良性肿瘤患者的临床资料。收集三阴性乳腺癌患者的病理组织和癌旁正常乳腺组织,以及乳腺良性肿瘤患者的病理组织,采用免疫组织化学法检查各组织中的LDLR表达情况,比较不同组织的LDLR得分,分析三阴性乳腺癌患者无病生存和总生存的危险因素。结果 三阴性乳腺癌组织LDLR得分高于乳腺良性肿瘤组织和三阴性乳腺癌的癌旁组织[3(2,8)分比3(3,4)3(0,4)分],且乳腺良性肿瘤组织LDLR得分高于三阴性乳腺癌的癌旁组织(均P0.001)。多因素回归分析结果显示,LDLR得分和淋巴结转移为三阴性乳腺癌无病生存的独立影响因素(比值比=0.5362.62495%置信区间:0.295~0.9741.397~4.930,均P0.05),淋巴结转移是影响三阴性乳腺癌总生存的独立危险因素(比值比=5.26895%置信区间:2.412~11.506P0.001)结论  三阴性乳腺癌组织LDLR得分高于乳腺良性肿瘤组织和三阴性乳腺癌的癌旁组织。LDLR得分和淋巴结转移为三阴性乳腺癌患者无病生存的独立影响因素,检测LDLR有助于预测三阴性乳腺癌患者的无病生存期。

  • Objective   To investigate the effect of low-density lipoprotein receptor (LDLR) on the prognosis of patients with triple-negative breast cancer. Methods   The clinical data of 107 patients with triple-negative breast cancer and 136 patients with benign breast tumor admitted to Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2010 to December 2016 were retrospectively analyzed. The pathological tissues and adjacent normal breast tissues of patients with triple-negative breast cancer and pathological tissues of patients with benign breast tumor were collected. The expression of LDLR in each tissue was examined by immunohistochemistry. The LDLR score of different tissues was compared, and the risk factors for disease-free survival and overall survival were analyzed in patients with triple-negative breast cancer. Results  The LDLR score of triple-negative breast cancer tissues was higher than that of benign breast tumor tissues and triple-negative breast cancer adjacent tissues 3(2,8) vs 3(3,4), 3(0,4), and LDLR score of benign breast tumor was higher than that of triple-negative breast cancer adjacent tissues (all P<0.001). Multivariate regression analysis showed that LDLR score and lymph node metastasis were independent factors affecting the disease-free survival of triple-negative breast cancer (odds ratio=0.536 and 2.624, 95% confidence interval: 0.295-0.974 and 1.397-4.930, both P<0.05). Lymph node metastasis was an independent risk factor affecting the overall survival of triple-negative breast cancer (odds ratio=5.268, 95% confidence interval: 2.412-11.506, P<0.001). Conclusions The LDLR score of triple-negative breast cancer tissues is higher than that of benign breast tumor tissues and triple-negative breast cancer adjacent tissues. LDLR score and lymph node metastasis are independent factors affecting the disease-free survival of patients with triple-negative breast cancer. Detection of LDLR is helpful to predict the disease-free survival of patients with triple-negative breast cancer.

copyright 《中国医药》杂志编辑部
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层
电话:010-64456116 传真:010-64428528 邮编:100029 Email: zgyy8888@163.com
网址:www.chinamedicinej.com 京ICP备2020043099号-3

当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com。







安卓


苹果

关闭