2022 年第 3 期 第 17 卷

微小RNA对高磷诱导血管钙化中Runt相关转录因子2表达调控作用的研究进展

Research progress on the regulation of Runt-related transcription factor 2 expression in high phosphorus induced vascular calcification by microRNA

作者：贾娟1王红杰2吴祯3张海松1

英文作者：Jia Juan1 Wang Hongjie2 Wu Zhen3 Zhang Haisong1

单位：1河北大学附属医院肾脏内科，保定071000；2河北大学附属医院麻醉科，保定071000；3河北大学临床医学院，保定071000

英文单位：1Department of Nephrology Affiliated Hospital of Hebei University Baoding 071000 China; 2Department of Anesthesiology Affiliated Hospital of Hebei University Baoding 071000 China; 3School of Clinical Medicine Hebei University Baoding 071000 China

关键词：血管钙化；高磷；微小RNA；Runt相关转录因子2

英文关键词：Vascularcalcification;Highphosphorus;MicroRNA;Runt-relatedtranscriptionfactor2

• 摘要：

• 高磷血症是导致慢性肾脏病及终末期肾脏病患者血管钙化的独立危险因素。在高磷环境的刺激下，血管平滑肌细胞可表达Runt相关转录因子2（Runx2），促进血管平滑肌细胞向成骨样细胞转化。而微小RNA（miRNA）可通过转录后负性调控靶细胞Runx2表达起到促进或抑制血管钙化的作用。本文对在高磷状态下与血管平滑肌细胞产生Runx2相关的miRNA的研究进行综述。

• 】Hyperphosphatemia is an independent risk factor for vascular calcification in patients with chronic kidney disease and end-stage renal disease. Under the high phosphorus environment, vascular smooth muscle cells (VSMCs) express Runt-related transcription factor 2 (Runx2) which facilitates the transformation VSMCs into osteoblasts. MicroRNA (miRNA) can promote or inhibit vascular calcification by negatively regulating the expression of Runx2 in target cells after transcription. This paper reviews the research on miRNA related to Runx2 producted by vascular smooth muscle cells under high phosphorus conditions.