2022 年第 8 期 第 17 卷

常规治疗联合喜炎平注射液治疗慢性支气管炎急性发作的临床效果观察

Clinical effect of conventional therapy combined with Xiyanping injection on acute attack of chronic bronchitis

作者：范存尧1郑磊2崔方博3

英文作者：Fan Cunyao1 Zheng Lei2 Cui Fangbo3

单位：1安徽省马鞍山市人民医院药事科，马鞍山243000；2安徽省马鞍山市人民医院呼吸科，马鞍山243000；3安徽省马鞍山市人民医院肿瘤化疗科，马鞍山243000

英文单位：1Department of Pharmacy Maanshan People′s Hospital Anhui Province Maanshan 243000 China; 2Department of Respiratory Maanshan People′s Hospital Anhui Province Maanshan 243000 China; 3Department of Cancer Chemotherapy Maanshan People′s Hospital Anhui Province Maanshan 243000 China

关键词：支气管炎；喜炎平注射液；肺功能；C反应蛋白

英文关键词：Bronchitis;Xiyanpinginjection;Lungfunction;C-reactiveprotein

• 摘要：

• 目的 探讨在常规治疗基础上联合喜炎平注射液治疗慢性支气管炎急性发作的临床效果。方法 将2020年11月至2021年11月安徽省马鞍山市人民医院收治的66例慢性支气管炎急性发作患者简单随机分为对照组和观察组，各33例。2组患者均给予抗菌药物、补液、维持电解质平衡等措施进行常规治疗，对照组患者在常规治疗基础上给予等容量喜炎平模拟注射液静脉滴注；观察组患者在常规治疗基础上给予喜炎平注射液静脉滴注。比较2组临床疗效、治疗前后肺功能指标［第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1与FVC比值（FEV1/FVC比值）］、C反应蛋白（CRP）水平及不良反应发生率。结果 观察组1例中途退出，对照组无脱落，观察组总有效率高于对照组，差异有统计学意义［96.9%（31/32）比78.8%（26/33）］（P<0.05）。治疗后，2组FEV1、FVC及FEV1/FVC比值均高于治疗前，且观察组均高于对照组，CRP均低于治疗前，且观察组低于对照组，差异均有统计学意义（均P<0.05）。2组患者头晕出汗等不良反应的发生率差异无统计学意义（P>0.05）。结论 在常规治疗基础上联合喜炎平注射液治疗慢性支气管炎急性发作的效果较好，能够有效改善患者的肺功能，抑制炎症反应，安全可靠。

• Objective To explore the clinical effect of conventional therapy combined with Xiyanping injection on acute attack of chronic bronchitis. Methods A total of 66 patients with acute attack of chronic bronchitis admitted to Maanshan People′s Hospital, Anhui Province from November 2020 to November 2021 were enrolled. Patients were randomly divided into control group and observation group, with 33 cases in each group. Both groups of patients were given antibiotics, fluid replacement, maintenance of electrolyte balance and other measures for conventional therapy. On this basis, patients in the control group were given equal volume Xiyanping simulated injection intravenous drip, and patients in the observation group were given Xiyanping injection intravenous drip. The clinical efficacy, levels of pulmonary function indexes［forced expiratory volume in the first second(FEV1), forced vital capacity(FVC), ratio of FEV1 to FVC(FEV1/FVC ratio)］, C-reactive protein(CRP) before and after treatment and incidence of adverse reactions in the two groups were observed. Results One case in the observation group quitted midway, and patients in the control group did not fall-off. The total effective rate in the observation group was higher than that in the control group［96.9%(31/32) vs 78.8%(26/33)］(P<0.05). After treatment, FEV1, FVC and FEV1/FVC ratio in both groups were higher than those before treatment, and those levels in the observation group were higher than those in the control group; levels of CRP in both groups were lower than those before treatment, and the level in the observation group was lower than that in the control group(all P<0.05). There was no significant difference in the incidence of adverse reactions such as dizziness and sweating between the two groups(P>0.05). Conclusions  On the basis of conventional therapy, Xiyanping injection to treat acute attack of chronic bronchitis has a better effect. It can effectively improve the lung function of patients, inhibit inflammation, and is safe and reliable.