2022 年第 8 期 第 17 卷

免疫调节分子VSIG4在炎症性疾病中的作用机制研究进展

Research progress on mechanism of V-set and immunoglobulin domain-containing protein 4 in inflammatory diseases 

作者：李猷王旗陈颖卿王茜茜

英文作者：Li You Wang Qi Chen Yingqing Wang Qianqian

单位：大连大学医学院慢性病研究中心大连市重点研究室，大连116622

英文单位：Chronic Disease Research Center Key Laboratory of Dalian Medical College Dalian University Dalian 116622 China

关键词：炎症性疾病；VSIG4；分子机制

英文关键词：Inflammatorydisease;V-setandimmunoglobulindomain-containingprotein4;Molecularmechanism

• 摘要：

• 免疫调节分子VSIG4是一种特异性表达于巨噬细胞的B7家族相关蛋白的Ⅰ型跨膜蛋白，既具有抑制T细胞增殖与活化的能力，又能作为补体受体清除补体C3包被的病原体或自身抗原。近年研究显示，作为致癌基因的VSIG4不仅在癌症中发挥作用，在多种炎症性疾病如实验性自身免疫性脑脊髓炎、炎症性肠炎、肝炎以及关节炎等多种疾病也起着至关重要的作用。为了更加系统地了解VSIG4在炎症性疾病中的作用以及作用机制，本文总结归纳VSIG4在炎症性疾病中所涉及的分子机制或通路，以期为VSIG4治疗炎症性疾病的方法和手段提供科学依据，并进一步为VSIG4在炎症性疾病中的临床应用提供理论支撑。

• The immunomodulatory molecule V-set and immunoglobulin domain-containing protein 4 (VSIG4) is a type Ⅰ transmembrane protein specifically expressed in B7 family-related proteins of macrophages. It can not only inhibit the proliferation and activation of T cells, but also act as a complement receptor to remove complement C3-coated pathogens or autoantigens. Recent studies have shown that VSIG4, as an oncogene, not only plays a role in cancer, but also plays an important role in a variety of inflammatory diseases such as experimental autoimmune encephalomyelitis, inflammatory enteritis, hepatitis and arthritis. In order to understand the role and mechanism of VSIG4 in inflammatory diseases more systematically, this paper summarizes the molecular mechanisms or pathways involved in VSIG4 in inflammatory diseases, in order to provide scientific basis for the methods and means of VSIG4 in the treatment of inflammatory diseases, and further provide data support for the clinical application of VSIG4 in inflammatory diseases.