2022 年第 10 期 第 17 卷

髓源性抑制细胞在肿瘤微环境中作用的研究进展

Research advances of the functions of myeloid-derived suppressor cells in tumor microenvironment

作者：崔维刚1时会芳2张敏2宋振毓2秦燕2律洁2

英文作者：Cui Weigang1 Shi Huifang2 Zhang Min2 Song Zhenyu2 Qin Yan2 Lyu Jie2

单位：1山东省日照市人民医院中心实验室，日照276800；2山东省日照市人民医院检验科，日照276800

英文单位：1Department of Central Laboratory People′s Hospital of Rizhao Shandong Province Rizhao 276800 China; 2Department of Clinical Laboratory People′s Hospital of Rizhao Shandong Province Rizhao 276800 China

关键词：髓源性抑制细胞；肿瘤微环境；免疫抑制；血管生成；侵袭转移；免疫治疗

英文关键词：Myeloid-derivedsuppressorcells;Tumormicroenvironment;Immunosuppression;Angiogenesis;Invasionandmetastasis;Immunitytherapy

• 摘要：

• 肿瘤微环境在肿瘤进展过程中发挥至关重要的作用，髓源性抑制细胞（MDSC）是介导微环境免疫抑制效应的关键组分。MDSC在骨髓中产生，并通过多种趋化因子募集至外周淋巴器官和肿瘤组织中来促进肿瘤微环境的形成。除免疫抑制作用外，MDSC在肿瘤微环境中还可以通过促进肿瘤内血管生成、肿瘤细胞侵袭转移能力等机制发挥促肿瘤效应。本文从MDSC的起源、分类、扩增活化机制、趋化因子、在肿瘤微环境中的功能以及以MDSC为靶点的免疫治疗等方面入手，就近几年的相关研究进行综述。

• The survival and development of tumor cells are dependent on the tumor microenvironment, which plays a significant role in the tumor progression. Myeloid-derived suppressor cells (MDSC) are one of the key components that mediate the immunosuppressive effect of the microenvironment. MDSC are generated in the bone marrow, and recruited into the peripheral lymphoid organs and the tumor to contribute to the formation of the tumor microenvironment.In the tumor microenvironment, MDSC accelerate the progression of tumor by promoting intratumoral angiogenesis, tumor cell invasion and metastasis in addition to immunosuppression. In this review, we mainly conclude the origin, classification, expansion, activition and chemokines of MDSC, and focus on the functions and targeted therapy of MDSC in the tumor micronevironment.