2023 年第 6 期 第 18 卷

冠状动脉慢血流的发病机制及其DNA甲基化研究进展

Advances in the pathogenesis and DNA methylation of coronary slow flow

作者：刘用肖狄康静璠张立晶

英文作者：Liu Yong Xiao Di Kang Jingfan Zhang Lijing

单位：北京中医药大学东直门医院心血管内科，北京100700

英文单位：Department of Cardiovascular Medicine Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700 China

关键词：冠状动脉慢血流；DNA甲基化；动脉粥样硬化

英文关键词：Coronaryslowflow；DNAmethylation；Atherosclerosis

• 摘要：

• 冠状动脉慢血流（CSF）在临床中较为常见，1%～7%的冠状动脉造影患者可诊断为CSF，且呈逐年上升的趋势。CSF常伴有心绞痛反复发作，严重影响患者的生活质量。关于CSF的机制研究主要集中在动脉粥样硬化、血管内皮功能障碍、炎症反应等，DNA甲基化作为目前研究最为成熟的表观遗传学修饰方法之一，与上述机制密切相关。本文将从DNA甲基化的角度对CSF的发生机制进行综述，以期为临床防治CSF提供新的思路。

• Coronary slow flow (CSF) is common in clinical practice. About 1%-7% of patients with coronary angiography can be diagnosed as CSF, with an increasing trend year by year. CSF often occurs repeatedly with angina pectoris, which seriously affects the quality of life of patients. The research on the mechanism of CSF mainly focuses on atherosclerosis, endothelial dysfunction, inflammatory reaction, and so on. DNA methylation, as one of the most mature epigenetic modification methods, is closely related to the above mechanisms. This article reviews the mechanism of CSF from the perspective of DNA methylation, in order to provide new ideas for clinical prevention and treatment of CSF.