2023 年第 9 期 第 18 卷

高迁移率族蛋白B1与脓毒症相关性的研究进展

Research progress of high mobility group protein B1 and sepsis

作者：饶玉薪,孙慧

英文作者：Rao Yuxin Sun Hui

单位：贵州医科大学附属医院儿童重症监护室，贵阳550000

英文单位：Pediatric Intensive Care Unit Affiliated Hospital of Guizhou Medical University Guiyang 550000 China

关键词：脓毒症；高迁移率族蛋白B1；特征；关系；预后

英文关键词：Sepsis;HighmobilitygroupproteinB1;Characteristic;Relationship;Prognosis

• 摘要：

• 脓毒症是一种致命的器官功能障碍，是由于身体对感染的不可控反应引起，是全世界重症监护室患者的主要死因之一。在脓毒症中，细胞因子的大量释放引发了不受控制的促炎症反应，可导致组织损伤和器官功能障碍。高迁移率族蛋白B1（HMGB1）作为一种晚期、下游的致命性炎症介质参与脓毒症的发病机制，研究HMGB1的特性，了解HMGB1与脓毒症的关系，有助于开发新的治疗靶点，以干预脓毒症的预防和治疗，降低患者死亡率，改善患者生活质量。

• Sepsis is a fatal organ dysfunction caused by the body′s uncontrollable response to infection and is one of the leading causes of death for patients in intensive care units around the worldwide. In sepsis, the massive release of cytokines triggers an uncontrolled pro-inflammatory response leading to tissue damage and organ dysfunction. High mobility group protein B1 (HMGB1) is involved in the pathogenesis of sepsis as a late, downstream mediator of lethal inflammation. Researchers will continue to investigate the properties of HMGB1 to understand its relationship with sepsis and continue to develop new therapeutic targets to intervene in the prevention and treatment of sepsis to reduce mortality and improve survival and quality of life in patients with sepsis.