2023 年第 11 期 第 18 卷

维生素D在注意缺陷多动障碍发病机制中的研究进展

Research progress of vitamin D in the pathogenesis of attention deficit hyperactivity disorder

作者：王慧婷刘子奇杨健

英文作者：Wang Huiting Liu Ziqi Yang Jian

单位：首都儿科研究所附属儿童医院神经内科，北京100020

英文单位：Department of Neurology Children′s Hospital Capital Institute of Pediatrics Beijing 100020， China

关键词：注意缺陷多动障碍；维生素D；发病机制

英文关键词：Attentiondeficithyperactivitydisorder;VitaminD;Pathogenesis

• 摘要：

• 注意缺陷多动障碍（ADHD）是一种儿童期发病的神经发育障碍，遗传因素与环境因素均在发病中起作用。近年来研究表明ADHD患者可伴有维生素D缺乏，补充维生素D可改善患者的部分临床症状。维生素D是一种脂溶性维生素，通过与维生素D受体结合发挥作用，除具有调节钙磷代谢作用外，还具有调节免疫功能的作用。本文主要从维生素D在ADHD中发挥的调节细胞因子、氧化应激、神经营养因子、神经递质、神经元周围基质网络及调节肠道菌群方面作用机制进行综述。

• Attention deficit hyperactivity disorder (ADHD) is a childhood neurodevelopmental disorder in which both genetic and environmental factors play a role. Recent studies have shown that patients with ADHD can be accompanied by vitamin D deficiency, and vitamin D supplementation can improve some of the clinical symptoms of patients. Vitamin D is a fat-soluble vitamin that acts by binding to the vitamin D receptor. It not only regulates calcium and phosphorus metabolism, but also regulates immune function. This review focuses on the mechanisms of vitamin D in regulating cytokines, oxidative stress, neurotrophic factors, neurotransmitters, perineuronal nets, and intestinal flora in ADHD.