2023 年第 11 期 第 18 卷

神经菌毛素1参与肝细胞癌侵袭及转移的研究进展

Research progress of neuropilin 1 involved in invasion and metastasis of hepatocellular carcinoma

作者：林熊1王雨2周塏3刘路政4武金才1

英文作者：Lin Xiong1 Wang Yu2 Zhou Kai3 Liu Luzheng4 Wu Jincai1

单位：1海南医学院附属海南医院海南省人民医院肝胆胰外科，海口570311；2海南医学院附属海南医院海南省人民医院老年医学中心科，海口570311；3海南医学院附属海南医院海南省人民医院运动医学科，海口570311；4海南医学院第二附属医院介入血管外科，海口570216

英文单位：1Department of Hepatobiliary and Pancreatic Surgery Hainan Affiliated Hospital of Hainan Medical University Hainan General Hospital Haikou 570311 China; 2Department of Geriatrics Center Hainan Affiliated Hospital of Hainan Medical University Hainan General Hospital Haikou 570311 China; 3Department of Sports Medicine Hainan Affiliated Hospital of Hainan Medical University Hainan General Hospital Haikou 570311 China; 4Department of Interventional Vascular Surgery the Second Affiliated Hospital of Hainan Medical University Haikou 570216 China

关键词：肝细胞癌；神经菌毛素1；微小RNA

英文关键词：Hepatocellularcarcinoma;Neuropilin1；MicroRNA

• 摘要：

• 肝细胞癌是世界上极具侵袭性的实体恶性肿瘤之一，发病隐匿，早期易发生浸润和转移，导致多数患者确诊时已失去手术最佳时期。神经菌毛素1（NRP1）在肝细胞癌中发挥巨大的作用，其可促进血管生成、肿瘤生长以及肿瘤侵袭和转移，甚至介导免疫逃逸，值得注意的是，NRP1还可与微小RNA相互作用介导肝细胞癌的发生、发展。故进一步研究NRP1在肝细胞癌中的作用机制，使其未来能够作为肿瘤侵袭转移的诊断标志物以及新治疗靶点具有极其重要的意义。本文将从NRP1出发，对其与肝细胞癌之间的关系以及介导的肿瘤侵袭转移的潜在机制进行综述。

• Hepatocellular carcinoma (HCC) is one of the most aggressive solid malignant tumors in the world. The onset of HCC is occult, and it is easy to infiltrate and metastasized in the early stage, which leads to the loss of the optimal period of surgery when most patients are diagnosed. Studies have shown that neuropilin 1 (NRP1) plays a huge role in HCC, promoting angiogenesis, tumor growth, tumor invasion and metastasis, and even mediating immune escape, it is worth noting that NRP1 can also interact with microRNA to mediate the occurrence and development of HCC. Moreover, it is of great significance to further study the mechanism of NRP1 in HCC, so that it can be used as a diagnostic marker of tumor invasion and metastasis and a new therapeutic target in the future. This paper starts from NRP1 to explore the relationship between NRP1 and HCC and the potential mechanism of tumor invasion and metastasis mediated by NRP1.