2024 年第 1 期 第 19 卷

基于信号通路探讨中医药干预阿尔茨海默病的研究进展

Research progress of traditional Chinese medicine intervention in Alzheimer′s disease based on signaling pathways

作者：谢鑫玉1 孟毅2 乔明亮2 王颖楠1 姚尾尾1

英文作者：Xie Xinyu1 Meng Yi2 Qiao Mingliang2 Wang Yingnan1 Yao Weiwei1

单位：1河南中医药大学第二临床医学院，郑州450000；2河南省中医院老年病科，郑州450000

英文单位：1The Second Clinical Medical College of Henan University of Chinese Medicine Zhengzhou 450000 China; 2Department of Geriatrics Henan Province Hospital of Traditional Chinese Medicine Zhengzhou 450000 China

关键词：阿尔茨海默病；中医药；信号通路

英文关键词：Alzheimer′sdisease;TraditionalChinesemedicine;Signalingpathway

• 摘要：

• 阿尔茨海默病（AD）是一种年龄依赖性的神经退行性疾病，被认为是痴呆最常见的类型。近年来中医药在AD的治疗中发挥了重要作用，探索中医药预防和治疗AD的机制研究较多，研究表明中药单体及中药复方均可通过靶向信号因子调控AD相关信号通路以延缓疾病进展。本文通过对参与AD病理形成过程的相关信号转导通路及中医药防治的作用机制等研究成果进行综述，以期为临床诊治AD提供参考依据。

• Alzheimer′s disease (AD) is an age-dependent neurodegenerative disease that is considered to be the most common type of dementia. In recent years, traditional Chinese medicine has played an important role in the treatment of AD. Many studies have explored the mechanism of traditional Chinese medicine in the prevention and treatment of AD. Studies have shown that both traditional Chinese medicine monomers and traditional Chinese medicine compounds can regulate AD-related signaling pathways by targeting signaling factors to delay the progression of the disease. This article reviews the research results of signal transduction pathways involved in the pathological process of AD and the mechanism of action of traditional Chinese medicine in the prevention and treatment of AD, in order to provide reference for clinical diagnosis and treatment of AD.