2024 年第 2 期 第 19 卷

系统性红斑狼疮伴发急性髓系白血病1例并文献复习

Systemic lupus erythematosus complicated with acute myeloid leukemia: a case report and literature review

作者：丁婉1张小艳1朱淳2李慧凛3

英文作者：Ding Wan1 Zhang Xiaoyan1 Zhu Chun2 Li Huilin3

单位：1上海交通大学医学院附属新华医院肾脏风湿免疫科，上海200092；2上海健康医学院附属崇明医院肾脏内科，上海202150；3上海市浦东新区公利医院肾内科，上海200135

英文单位：1Department of Renal Rheumatology and Immunology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China; 2Department of Nephrology Chongming Branch of Shanghai Health Medical College Shanghai 202150 China; 3Department of Nephrology Pudong Gongli Hospital Shanghai Shanghai 200135 China

关键词：系统性红斑狼疮；急性髓系白血病；急性白血病

英文关键词：Systemiclupuserythematosus;Acutemyeloidleukemia;Acutemyeloid

• 摘要：

• 本文报道了1例系统性红斑狼疮（SLE）伴发急性髓系白血病（AML）患者的临床表现及诊治经过，该例为SLE肾损害8年的女性患者，经免疫抑制治疗后完全缓解，因发热、牙龈肿痛伴血细胞异常进一步明确诊断为AML，经过规律化疗患者达完全缓解。因SLE伴发AML较少见，本文结合文献检索已报道的相关病例的临床特征，探讨两种疾病的相关性及可能发生机制和影响因素，提高临床医生对该病的认识，减少漏诊和误诊的发生，以期早诊断，早治疗，改善患者预后。

• This paper reports the clinical manifestations, diagnosis and treatment of a patient with systemic lupus erythematosus (SLE) complicated with acute myeloid leukemia (AML). A female patient with renal involvement in SLE for 8 years achieved complete remission after immunosuppressive therapy. The patient was further diagnosed with AML because of fever, gingival swelling and pain with abnormal blood cells. After regular chemotherapy, the patient achieved complete remission. Since SLE complicated with AML is rare, this article reviews the clinical characteristics of related cases reported in the literature to explore the correlation, possible mechanism and influencing factors of the two diseases, so as to improve clinicians′ understanding of the disease, reduce the occurrence of missed diagnosis and misdiagnosis, so as to make early diagnosis and treatment, and improve the prognosis of patients.