2024 年第 2 期 第 19 卷

炎症反应在原发性高血压病中作用的研究进展

Advances in the role of inflammatory response in essential hypertension

作者：刘晓萌1,2刘高卿3曹园圆2谢梦欣2孙彦琴1闫奎坡1

英文作者：Liu Xiaomeng12 Liu Gaoqing3 Cao Yuanyuan2 Xie Mengxin2 Sun Yanqin1 Yan Kuipo1

单位：1河南中医药大学第一附属医院心脏中心/国家区域(中医)心血管诊疗中心，郑州450000；2河南中医药大学第一临床医学院，郑州450000；3河南中医药大学骨伤学院，郑州450000

英文单位：1Heart Center the First Affiliated Hospital of Henan University of Chinese Medicine National and Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center Zhengzhou 450000 China; 2the First Clinical School Henan University of Chinese Medicine Zhengzhou 450000 China; 3College of Orthopaedics and Traumatology Henan University of Chinese Medicine Zhengzhou 450000 China

关键词：高血压病；炎症反应；炎性细胞因子；信号通路

英文关键词：Hypertension;Inflammatoryresponse;Inflammatorycytokines;Signalingpathways

• 摘要：

• 原发性高血压病（EH）是常见的慢性病之一，其发病率高，是心血管疾病最突出的危险因素。研究表明炎症反应在高血压病的发生、发展及转归中扮演着极其重要的角色，炎症因子、炎症相关信号通路等均参与EH的发病。本文对EH相关炎症反应进行综述，以期更好地揭示炎症反应在EH发生发展中的作用，为EH在临床中的预防和治疗以及相关的基础实验研究提供思路。

• Essential hypertension (EH), one of the most common chronic diseases with a high incidence, is the most prominent risk factor for cardiovascular disease. Recent studies have shown that inflammation plays an extremely important role in the occurrence, development and outcome of hypertension, and inflammatory factors and inflammation-related signaling pathways are involved in the pathogenesis of EH. This review is aimed at better revealing the role of inflammation in the occurrence and development of EH, in order to provide ideas for the prevention and treatment of EH in clinic and related basic experimental research.