2024 年第 4 期 第 19 卷

冠心苏合胶囊联合硝苯地平控释片治疗不稳定型心绞痛的临床效果研究

Clinical study of Guanxinsuhe capsule combined with nifedipine controlled release tablets in the treatment of unstable angina pectoris

作者：刘洋

英文作者：Liu Yang

单位：黑龙江省第二医院心内三科，哈尔滨150000

英文单位：The Third Department of Cardiology the Second Hospital of Heilongjiang Province Harbin 150000 China

关键词：不稳定型心绞痛；冠心苏合胶囊；硝苯地平控释片

英文关键词：Unstableanginapectoris;Guanxinsuhecapsule;Nifedipinecontrolledreleasetablets

• 摘要：

• 目的 探讨冠心苏合胶囊联合硝苯地平控释片治疗不稳定型心绞痛（UAP）的临床效果。方法 将2021年5月到2023年5月在黑龙江省第二医院接受治疗的104例UAP患者按随机数字表法分为观察组（52例）和对照组（52例）。对照组口服硝苯地平控释片进行治疗，观察组口服冠心苏合胶囊以及硝苯地平控释片进行治疗。在治疗30 d后进行疗效评价，比较2组患者治疗前后的血清炎症因子和血液流变学指标，比较2组患者的不良反应发生情况。结果 观察组总有效率高于对照组［94.2%（49/52）比80.8%（42/52）］，差异有统计学意义（P=0.038）。治疗30 d后，2组患者血清基质金属蛋白酶9、白细胞介素18、C反应蛋白水平均明显低于治疗前，且观察组均低于对照组（均P＜0.05）。治疗30 d后，2组患者纤维蛋白原、低切全血黏度、中切全血黏度、高切全血黏度、血浆黏度均明显低于治疗前，且观察组均低于对照组（均P＜0.05）。对照组不良反应发生率与观察组比较［5.8%（3/52）比9.6%（5/52）］，差异无统计学意义（P=0.713）。结论 冠心苏合胶囊联合硝苯地平控释片治疗UAP具有较好的临床效果，可有效改善患者的炎症状态和血液高凝状态，且安全性较好。

• Objective To investigate the clinical efficacy of Guanxinsuhe capsule combined with nifedipine controlled release tablets in the treatment of unstable angina pectoris (UAP). Methods Totally 104 UAP patients admitted to the Second Hospital of Heilongjiang Province from May 2021 to May 2023 were divided into observation group (52 cases) and control group (52 cases) by the random number table method. The control group was treated with nifedipine controlled release tablets orally, and the observation group was treated with Guanxinsuhe capsule and nifedipine controlled release tablets orally. The clinical efficacy was evaluated after 30 d of treatment. The serum inflammatory factors and hemorheology indexes of the two groups were compared before and after treatment, and the adverse reactions of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group［94.2%(49/52) vs 80.8%(42/52)］(P=0.038). After 30 d of treatment, the serum levels of matrix metalloproteinase-9, interleukin-18 and C-reactive protein in both groups were significantly lower than those before treatment, and the levels in the observation group were lower than those in the control group (all P＜0.05). After 30 d of treatment, fibrinogen, low shear whole blood viscosity, medium shear whole blood viscosity, high shear whole blood viscosity, and plasma viscosity in both groups were significantly lower than those before treatment, and the above indicators in the observation group were lower than those in the control group (all P＜0.05). There was no statistically significant difference in the incidence of adverse reactions between the control group and the observation group［5.8%(3/52) vs 9.6%(5/52)］(P=0.713). Conclusion Guanxinsuhe capsule combined with nifedipine controlled release tablet has a good clinical effect in the treatment of UAP, which can effectively improve the inflammatory state and hypercoagulable state of blood in patients, and the safety is good.