2024 年第 6 期 第 0 卷

肠道菌群及其代谢产物在糖尿病肾病中的研究进展

Research progress of intestinal flora and its metabolites in diabetic nephropathy

作者：张晴王俭勤

英文作者：Zhang Qing Wang Jianqin

单位：兰州大学第二医院肾脏内科，兰州730000

英文单位：Department of Nephrology the Second Hospital Lanzhou University Lanzhou 730000 China

关键词：糖尿病肾病；肠道菌群；代谢物；炎症

英文关键词：Diabeticnephropathy;Intestinalflora;Metabolites;Inflammation

• 摘要：

• 糖尿病肾病（DN）是终末期肾病的重要原因，但其机制尚未完全明确，目前认为是由遗传、免疫、炎症、胰岛素抵抗和氧化应激等因素共同作用的结果。近年来研究发现，肠道菌群在DN患者与健康人群间存在差异，肠道菌群可通过释放内毒素及其有害代谢产物介导全身及肾脏局部炎症反应参与DN的进展，因此探究肠道菌群在DN患者肾脏病变中的作用有望为DN的诊断和治疗提供新思路。

• Diabetic nephropathy (DN) is an important cause of end-stage renal disease, but its mechanism is not fully understood. At present, it is considered to be the result of the interaction of genetics, immunity, inflammation, insulin resistance, oxidative stress and other factors. Recent studies have found that there are differences in intestinal flora between DN patients and healthy people, and intestinal flora can participate in the progression of DN by releasing endotoxin and its harmful metabolites to mediate systemic and renal inflammation. Therefore, exploring the role of intestinal flora in renal lesions of DN patients is expected to provide new ideas for the diagnosis and treatment of DN.