2024 年第 11 期 第 19 卷

驱动盐敏感性高血压形成的肾被膜下层细胞的研究进展

Research progress of renal subcapsular cells that drive the development of salt-sensitive hypertension

作者：高丹1陈潇1程丽萍1刘卫2马晓雯2

英文作者：Gao Dan1 Chen Xiao1 Cheng Liping1 Liu Wei2 Ma Xiaowen2

单位：1中国人民解放军联勤保障部队第九六六医院药剂科，丹东118000；2中国人民解放军联勤保障部队第九六〇医院药剂科，济南251012

英文单位：1Department of Pharmacy the 966th Hospital of the Joint Logistic Support Force of the Chinese People′s Liberation Army Dandong 118000 China; 2Department of Pharmacy the 960th Hospital of the Joint Logistic Support Force of the Chinese People′s Liberation Army Jinan 251012 China

关键词：盐敏感性高血压；肾损伤；肾脏被膜；上皮细胞钠离子通道

英文关键词：山东省自然科学基金（ZR2020QH349）

• 摘要：

• 盐敏感性高血压作为高血压的一种，多发于西北及东北地区，发病机制相当复杂。目前有从长期应用盐后导致肾素-血管紧张素-醛固酮系统发生紊乱来解释盐敏感性高血压的；有从基因角度来研究盐敏感性高血压的；也有从受体信号通路被激活进行研究的。本综述将着重从新发现的肾脏被膜下层细胞的钠离子通道对盐敏感性高血压进行论述。

• Salt-sensitive hypertension, as a kind of hypertension, is more common in northwest and northeast China, and its pathogenesis is quite complex. Currently, there are explanations for salt-sensitive hypertension that result from long-term use of salt leading to disorders in the renin-angiotensin-aldosterone system, as well as studies from a genetic perspective and those that investigate the activation of receptor signaling pathways. This review will focus on the newly discovered sodium channel of renal subdorsal membrane cells to discuss salt-sensitive hypertension.