2024 年第 11 期 第 0 卷

银杏叶提取物在抗动脉粥样硬化中的机制及临床应用进展

Progress in mechanism and clinical application of ginkgo biloba extract in anti-atherosclerosis

作者：田晋帆罗涵中刘立波安子玉宋现涛

英文作者：Tian Jinfan Luo Hanzhong Liu Libo An Ziyu Song Xiantao

单位：首都医科大学附属北京安贞医院心内冠心病中心一区，北京100029

英文单位：The First Ward of Coronary Heart Disease Center Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

关键词：银杏叶提取物；动脉粥样硬化；炎症；氧化应激

英文关键词：Ginkgobilobaextract;Atherosclerosis;Inflammation;Oxidativestress

• 摘要：

• 银杏叶提取物作为中国传统中药具有抗炎症、抗氧化、维持细胞生存、抑制血小板活化、扩张血管以及调节代谢等作用，广泛应用于临床治疗多种心血管疾病，尤其是动脉粥样硬化。在动脉粥样硬化治疗中，银杏叶提取物可以通过作用于5′-磷酸腺苷活化蛋白激酶-蛋白激酶B、丝裂原活化蛋白激酶、磷脂酰肌醇-3-激酶-蛋白激酶B、核因子E2相关因子-血红素加氧酶1多种通路发挥保护效应。本文对银杏叶提取物治疗动脉粥样硬化的机制及临床应用作一综述。

• Ginkgo biloba extract (GBE), as a traditional Chinese medicine, has the functions of anti-inflammation, anti-oxidation, maintaining cell survival, inhibiting platelet activation, dilating blood vessels and regulating metabolism. It is widely used in clinical treatment of a variety of cardiovascular diseases, especially atherosclerosis. In the treatment of atherosclerosis, GBE can play a protective effect by acting on multiple pathways including 5′-adenosine monophosphate-activated protein kinase/protein kinase B, mitogen-activated protein kinase, phosphatidylinositol-3-kinase/protein kinase B, nuclear factor E2-related factor/heme oxygenase-1. This article reviews the mechanism and clinical application of GBE in the treatment of atherosclerosis.